Simian Virus 40

Simian Virus 40

The relationship between mesothelioma and Simian virus 40 (SV40) is one that continues to be investigated because there are mixed reviews within the medical community concerning a causal relationship. Some investigators have found a causative role while others have not. The conflicting evidence suggests the need for more research to better understand the interactions between SV40 and mesothelioma.

Asbestos cancer is a rare disease that usually develops in the lining of the lungs and its primary cause is asbestos exposure. SV40 is a DNA virus that contaminated polio vaccines between the 1950s and ’60s. Although the SV40-contaminated vaccines were successful in reducing the incidence of polio, questions regarding its safety began to emerge shortly after its use.

In the early 1960s, researchers found SV40 had the ability to transform hamster and human cells and induce tumor formation. After the discovery of SV40-like DNA sequences in mesothelioma samples in 1994, investigators have continued to test the causal relationship between SV40 and malignant pleural mesothelioma.

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Background on Simian Virus 40

Simian virus 40 is a virus that was initially discovered in 1960 in rhesus monkey kidney cells. At the time, Dr. Jonas Salk's and Dr. Albert Sabin's polio vaccines were made from these cells and the mass immunization program for polio had already begun. From 1955 to 1963, an estimated 10 to 30 million people in the United States were inadvertently exposed to SV40-contaminated polio vaccinations. The exposure was so significant that researchers believe 80 to 90 percent of all U.S. children under the age of 20 had received at least one polio vaccination potentially contaminated with SV40.

When 1961 reports indicated the injection of SV40 into hamsters could cause tumors, the U.S. government instituted a screening program requiring all new polio vaccinations to be free of SV40. However, vaccinations made prior to this regulation were not withdrawn from the mass immunization program and children continued to be exposed until 1963.

Conflicting Evidence about SV40

The amount of research that supports a causal relationship between mesothelioma and SV40 is significant enough to warrant concern. In animal testing, 100 percent of those injected with SV40 into the pleural space developed mesothelioma within three to six months. There is also a general consensus that 50 to 60 percent of malignant mesothelioma cases in the United States contain SV40.

  • Tumors

    In some studies, researchers have found human mesothelial cells to be uniquely susceptible to SV40, and have suggested that the virus and asbestos may act as co-carcinogens. SV40 has been detected in human tumors in more than 40 different laboratories and many of these tumors were mesothelioma. Although there is evidence of SV40 acting as a causative agent in the development of asbestos cancer, there is an equal amount of evidence arguing against this causal relationship.

  • SV40 Working Group

    With the intent of resolving the conflicting relationship between mesothelioma and SV40, the International SV40 Working Group was formed in 1997. The group included the majority of laboratories studying SV40 in human tissues. In a study funded by the National Cancer Institute, nine laboratories agreed to participate in the study, which tested tissue samples for traces of SV40. Each laboratory was given a set of 25 human mesothelioma samples and 25 normal lung tissue samples. The samples were not labeled and each laboratory used their own method for detecting SV40. Results showed that none of the mesothelioma samples were consistently positive for SV40, suggesting a lack of evidence for a causal relationship between mesothelioma and SV40.

  • Vaccinations

    Other studies showed similar results. In one evaluation of children born during the years that SV40-contaminated vaccinations were used, an overall difference in cancer incidence was not reported when comparing the group to children who received uncontaminated vaccinations. But for every study that shows a lack of evidence for a causal relationship between cancer and SV40, another study exists that show a possible correlation. Considering the conflicting evidence, the medical community has yet to accept or reject a causal relationship between mesothelioma and SV40. Researchers continue to investigate the issue and they hope to reach a conclusion through future studies.

Additional Resources

  1. Pass, I., Vogelzang, N., Carbone, M. (2005). Malignant Mesothelioma: Advances in Pathogenesis, Diagnosis, and Transitional Therapies. Springer: New York.
  2. Robinson, B. and Chahinian, P. (2002). Mesothelioma. Tallers Grafics Soler: UK.
  3. Carbone, M. and Pass, H et al. (2008). The Relationship Between Simian Virus 40 and Mesothelioma. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/18520265
  4. National Cancer Institute. Simian Virus 40 and Human Cancer. Retrieved from http://www.cancer.gov/cancertopics/factsheet/Risk/
  5. Rizzo, P. and Carbone, M. et al. (1999). Simian Virus 40 Present in Most United States Human Mesotheliomas, but it is Rarely Present in Non-Hodgkin's Lymphoma. Retrieved from http://www.ncbi.nlm.nih.gov/pubmed/10619511
  6. Science Daily. (2004, Sep. 25). No Role for Simian Virus 40 in Human Pleural Mesotheliomas. Retrieved from http://chestjournal.chestpubs.org/content/116/suppl_3/470S.full.pdf
  7. Centers for Disease Control and Prevention. (2007, Oct. 22). Frequently Asked Questions about Cancer, Simian Virus 40 and Polio Vaccine. Retrieved from http://www.cdc.gov/vaccinesafety/updates/archive/polio_and_cancer.htm
  8. Carbone, M. and Pass, H. et al. (2003). New Developments about the Association of SV40 with Human Mesothelioma. Retrieved from http://www.nature.com/onc/journal/v22/n33/abs/1206552a.html

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