Detecting Mesothelioma Earlier with New Blood Test, Nanotechnology

Researcher with samples in vials

One of the biggest hurdles in combating mesothelioma cancer has been an inability to accurately diagnose the disease early enough to treat it effectively.
Far too often, mesothelioma is not identified until it has metastasized, leading to a typically poor prognosis.

Help may be coming in the future.

Researchers in Zurich, Switzerland recently published a study involving new technology that may help detect mesothelioma much earlier than before with a
simple, noninvasive blood test.

Bernd Wollscheid, Ph.D., of the Institute of Molecular Systems Biology and lead researcher of the study, says the findings could become a significant step
toward more effective management of the disease in the future.

“There is certainly a need to develop new diagnostics for mesothelioma,” Wollscheid told Asbestos.com. “This is
where the field is going. If you could show that someone was in the process of developing the disease, therapies might work better. You could evaluate new
treatment options.”

The research involves Selected Reaction Monitoring (SRM) technology that can uncover newly identified, protein-derived biomarkers that tumor cells have
released into the circulatory system.

Researchers recently identified a signature group of protein biomarkers found exclusively in mesothelioma. The authors of the recent study believe their findings will complement mesothelin, the
most commonly used biomarker that has only limited diagnostic value for mesothelioma.

By identifying a panel of biomarkers instead of just one, researchers expect the new tool
will be a more accurate indicator of the disease.

“Our study shows that SRM assay technology enables the direct clinical evaluation of protein-derived candidate biomarker panels for which clinically
reliable (testing methods) currently do not exist,” wrote the authors of the study, which was published last month in Clinical Proteomics Journal.

Simplify the Diagnosis

Mesothelioma, which is diagnosed in an estimated 3,000 cases annually in the U.S., is caused by exposure to toxic asbestos. It can take between 10-50 years
between exposure and definitive diagnosis.

Symptoms often mirror those of less serious problems, and often don’t appear until decades after an inhalation or ingestion of microscopic asbestos fibers. They can be as simple as a dry cough, shortness of
breath, or night sweats, and excess fluid around the lungs.

Doctors typically begin with X-rays, MRIs, CT scans and PET scans when trying to diagnose the
problem, but even then the signs can be vague. Not until invasive biopsies are obtained is a
conclusive diagnosis delivered.

The new blood test could simplify the process and lead to a much earlier diagnosis. There
are other blood tests currently being used for mesothelioma, but with limited success. The most well-known one is the MESOMARK test, which involves
measuring the biomarker mesothelin.

Although MESOMARK is FDA approved, it has been more effective in measuring the progression of mesothelioma that already has been diagnosed, rather than the
early presence of mesothelioma.

Wollscheid believes the value of the recent findings will be in an ability to easily test high-risk patients (those who worked with asbestos) in order to
diagnosis it before it has spread, or even developed fully. It could change the way it is
treated.

“This is the future, not necessarily in the clinic in the next 2-5 years. This might not be helpful right now, but there is new technology out there,
giving us an ability to approach the problem differently down the road,” he said. “It needs more research certainly.”

This recent study was done collectively by scientists from the U.S., Sweden, Chile, Italy and Switzerland.

Nanotechnology Not Far Off

According to an unrelated study recently done in Germany, advancements in Nanotechnology – the manipulation of matter on a molecular
scale – is another path toward significant future help toward mesothelioma diagnostics.

Researchers from the West German Lung Center at the University Duisburg-Essen worked with a CytoViva Hyperspectral Imaging System, which evolved from
technology originally developed for NASA, to create high-contrast images of tissue samples.

The system was programed on a microscopic level to recognize the fingerprint of diseased lung tissue. The intent is a much less invasive procedure to
identify mesothelioma and lung cancer with a simple test.

“The software, once it had created a specific spectral library for each entity, was able to identify the same disease again in subsequent sets of slides of
the same disease,” wrote the authors in conclusion. “Further evaluation of this technique could make this illumination nanotechnology an efficient rapid,
on-site diagnostic tool.”

  1. Wollscheid, Bernd, Ph.D., Institute of Molecular Systems Biology, Zurich, Switzerland, interview with Asbestos.com. (2013, Dec. 6).
  2. http://www.clinicalproteomicsjournal.com/content/10/1/16
  3. http://www.ncbi.nlm.nih.gov/pubmed/24285923

Tim Povtak is an award-winning writer with more than 30 years of reporting national and international news. His most recent experience is in researching and writing about asbestos litigation issues and asbestos-related conditions like mesothelioma. If you have a story idea for Tim, please email him at tpovtak@asbestos.com

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