Sai Yendamuri

Sai Yendamuri M.D.

Attending Surgeon, Department of Thoracic Surgery; Director, Thoracic Laboratory; Associate Professor of Oncology

Specialty: Thoracic Surgery
Medical Treatment Center: Roswell Park Cancer Institute Elm Street, Buffalo, NY 14263

About Dr. Yendamuri

While the use of asbestos has dropped significantly in recent years and awareness of its dangers has improved, Dr. Sai Yendamuri still doesn’t expect any decline in cases of pleural mesothelioma he will see at Roswell Park Cancer Institute.

If anything, there will be more.

Yendamuri is a thoracic surgeon at Roswell, where he also serves as director of the facility’s thoracic laboratory. He expects that educational efforts will lead to earlier detection and improved success rates with mesothelioma.

Fast Fact: Dr. Yendamuri was interviewed as the mesothelioma medical expert by a Buffalo, New York, television station in 2011.

"Over the next few years, we will see dramatic improvement of mesothelioma care. There are better chemotherapy agents. Radiation therapy is getting more precise. Personalized care at the genetic level will happen,” he said during the center’s weekly Roswellness Radio program.

But he also emphasized that mesothelioma isn’t going away anytime soon.

“Ultimately I expect that the incidence will decrease because of the caution we’re exercising now with asbestos. But because of the latency period [the decades-long gap between first exposure and diagnosis], for that effect to show it’s going to take several more decades,” Yendamuri said.

Each year, 2,000 to 3,000 cases of mesothelioma are diagnosed in the U.S.

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Focus on Mesothelioma

Yendamuri is one of many oncologists who believe there is a clear and direct genetic link for those who develop mesothelioma.

Not everyone exposed to asbestos will get mesothelioma. It’s only a few who are genetically susceptible. We’ve grown to realize that most forms of cancer are a combination of genetic predisposition and environmental exposure. There is nothing about mesothelioma that suggests it’s anything else. It may not be as well defined now as in other cancers, but that’s probably just a question of time.

Yendamuri encourages patients and primary care physicians to take a more active role in looking for mesothelioma, which often is not diagnosed until it has reached a stage where the prognosis is grim.

“It is very commonly overlooked. And many physicians don’t ever see it, so it’s not high up there on things to look for,” he said. “If there is an older person who has been exposed to asbestos for a prolonged period of time and now develops a shortness of breath and fluid in the chest, that’s the kind of patient who could have mesothelioma.”

Yendamuri’s research interests include molecular staging of thoracic malignancies, lung cancer screening and risk prediction using genomic markers.

He received his degree from All India Institute of Medical Sciences in New Delhi, India. He completed his residencies at MD Anderson Cancer Center in Houston and the New York Hospital Medical Center of Queens/Cornell University.

A team at Roswell, including Yendamuri, published an article titled, “Thoracoscopic Extrapleural Pneumonectomy for Mesothelioma,” in the Annals of Thoracic Surgery in 2010.

Additional Resources

  1. Demmy, Todd L., Platis, Ioannis E., Nwogu, Chukwumere, Yendamuri, Sai (2011). Thoracoscopic Extrapleural Pneumonectomy for Mesothelioma. The Annals of Thoracic Surgery, 91, 616-618.
  2. McKinley, D. (Producer). (2011, May 5). Buffalo Lawmakers Okay Settling Cancer Suit Related To Mesothelioma [Television Broadcast]. Buffalo, NY: WGRZ-TV. Video Retrieved from http://www.wgrz.com/news/local/story.aspx?storyid=120417
  3. Roswell Park Cancer Institute – Sai Yendamuri, MD, FACS. (2011). Retrieved from http://www.roswellpark.org/sai-yendamuri
  4. Sai Yendamuri, MD (Author Responsibility). (2010, May 23). Dr. Yendamuri on Mesothelioma and Lung Cancer [nid67336]. Roswellness Radio. Podcast retrieved from http://www.roswellpark.org/media/audio/dr-yendamuri-mesothelioma-and-lung-cancer

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