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Papillary Mesothelioma

Papillary mesothelioma, known in the medical field as well-differentiated papillary mesothelioma (WDPM), is a rare variant of epithelial mesothelioma. This form of mesothelioma, in contrast with the conventional diffuse malignant mesothelioma (DMM), is considered to be of low malignant potential, or not likely to spread or invade other parts of the body.

Papillary Mesothelioma Treatments

Due to the rare occurrence of this disease, a recommendation of uniform treatment has yet to be established. The typical forms of treatment that have been documented in various studies are similar to traditional mesothelioma treatments and have included surgery and multiple forms of chemotherapy. Patients and their families often have numerous questions about the best way to combat mesothelioma and we offer a comprehensive packet with information about treatment options and top doctors, catered to each patient’s specific diagnosis. Please click here to receive this complimentary packet overnight.

Papillary Mesothelioma Tumors

Well-differentiated papillary mesothelioma tumors typically take an indolent clinical course (meaning the disease causes little to no pain and is relatively inactive and benign) and often bear a good prognosis. However, occasional cases of a more aggressive nature have been reported. In benign papillary mesothelioma instances, high rates of recurrence are relatively common.

Papillary mesothelioma tumors have most commonly developed in the peritoneum of women (usually of reproductive age), which is the mesothelial lining of the abdominal cavity. A number of WDPM cases have also occurred in the tunica vaginalis of the male reproductive system. In addition to these two areas, other cases have been reported in the pericardium (the mesothelial lining of the heart), pleura (the mesothelial lining of the lungs), and ovaries.

Development of Papillary Mesothelioma

Unlike the conclusive relationship between asbestos exposure and DMM, the majority of WDPM cases have developed without any known asbestos exposure. However, a number of patients involved in studies on WDPM have had a history of asbestos exposure ranging from occupational, secondary and household exposure.

Sources:

  1. Butnor, K., Sporn, T., Hammar, S. et al. Well-Differentiated Papillary Mesothelioma. (2001). The American Journal of Surgical Pathology: 1304-1309.
  2. Spano, J., Soria, J., Sabourin J. Well-Differentiated Papillary Mesothelioma (WDPM): Successful therapy by local surgery alone or combined with intraoperative intraperitoneal heated chemotherapy (IPHC) perfusion using cisplatin. (2003). Proceeding of the American Society for Clinical Oncology; 22.
  3. Lovell, F. and Cranston, P. Well-Differentiated Papillary Mesothelioma of the Peritoneum. (1990). American Journal of Roentgenology; 155:66, 1245-1246.
  4. http://www.ajronline.org/cgi/reprint/155/6/1245.pdf
  5. McCaughey, D. Well-Differentiated Papillary Mesothelioma of the Peritoneum: a clinicopathologic study of 22 cases. (1990). Cancer; 65: 292-296.
  6. Hoekstra, A., Riben, M., Frumovitz, M. et al. Well-Differentiated Papillary Mesothelioma of the Peritoneum: a athological analysis and review of the literature. (2005). Gynecologic Oncology; 98(1): 161-167.
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