Based on Your Reading:
Get Your Free Mesothelioma Guide
Find a Top Mesothelioma Doctor
Access Help Paying for Treatment
Papillary Mesothelioma
Table Of Contents
Papillary mesothelioma is a rare subtype of epithelial mesothelioma. Tumors form in the lining of the abdomen (peritoneum), the lining of the lungs (pleura) and the lining of the testes (tunica vaginalis).
Written by Karen Selby, RN • Edited By Walter Pacheco • Medically Reviewed By Dr. Rupesh Kotecha
Fact Checked
Our fact-checking process begins with a thorough review of all sources to ensure they are high quality. Then we cross-check the facts with original medical or scientific reports published by those sources, or we validate the facts with reputable news organizations, medical and scientific experts and other health experts. Each page includes all sources for full transparency.
Reviewed
Asbestos.com is the nation’s most trusted mesothelioma resource
The Mesothelioma Center at Asbestos.com has provided patients and their loved ones the most updated and reliable information on mesothelioma and asbestos exposure since 2006.
Our team of Patient Advocates includes a medical doctor, a registered nurse, health services administrators, veterans, VA-accredited Claims Agents, an oncology patient navigator and hospice care expert. Their combined expertise means we help any mesothelioma patient or loved one through every step of their cancer journey.
More than 30 contributors, including mesothelioma doctors, survivors, health care professionals and other experts, have peer-reviewed our website and written unique research-driven articles to ensure you get the highest-quality medical and health information.
About The Mesothelioma Center at Asbestos.com
- Assisting mesothelioma patients and their loved ones since 2006.
- Helps more than 50% of mesothelioma patients diagnosed annually in the U.S.
- A+ rating from the Better Business Bureau.
- 5-star reviewed mesothelioma and support organization.
Testimonials
My family has only the highest compliment for the assistance and support that we received from The Mesothelioma Center. This is a staff of compassionate and knowledgeable individuals who respect what your family is experiencing and who go the extra mile to make an unfortunate diagnosis less stressful. Information and assistance were provided by The Mesothelioma Center at no cost to our family.LashawnMesothelioma patient’s daughter
How to Cite Asbestos.com’s Article
APA
Selby, K. (2024, February 2). Papillary Mesothelioma. Asbestos.com. Retrieved April 19, 2024, from https://www.asbestos.com/mesothelioma/papillary/
MLA
Selby, Karen. "Papillary Mesothelioma." Asbestos.com, 2 Feb 2024, https://www.asbestos.com/mesothelioma/papillary/.
Chicago
Selby, Karen. "Papillary Mesothelioma." Asbestos.com. Last modified February 2, 2024. https://www.asbestos.com/mesothelioma/papillary/.
Where Does Papillary Mesothelioma Develop?
The majority of well-differentiated papillary mesothelioma (WDPM) tumors develop in women. It develops in the abdominal cavity.
Doctors have found WDPMT tumor growth on several of the body’s protective membranes. This includes the pleura (lining of the lungs), pericardium (heart sac) and tunica vaginalis (lining of the testes).
Is WDPMT Cancerous?
From a medical standpoint, these tumors are benign. Some cases have turned into malignant mesothelioma over time. The chance of this happening is unlikely. Some people with WDPMT have also experienced several recurrences after treatment.
Well-differentiated papillary mesothelioma.
Solid papillary mesothelioma tumors are benign or very low-grade tumors. Separation from malignant mesotheliomas is important. A 2021 research report in Modern Pathology reported this stance.
Is There an Asbestos Connection?
Researchers are unsure if asbestos exposure causes this tumor. Some patients have a history of asbestos exposure, but most do not. The cause of this disease remains.
About 50 cases of WDPMT in the peritoneum exist in the medical literature. A 2019 study published in Annals of Surgical Oncology reported this data. There are also several small case reports of WDPM of the pleura. About 20 documented cases of testicular papillary mesothelioma exist.
Symptoms and Characteristics
Many cases of well-differentiated papillary mesothelioma tumor have no symptoms. The disease causes pain and excessive fluid buildup in some patients.
Primary Characteristics of WDPMT
- Well-differentiated tumors are low grade. This means their cancer cells resemble healthy cells and grow and multiply at a slow rate.
- The cancer does not invade nearby tissues or spread throughout the body.
- WDPMT is completely inactive in some cases, showing no signs of cell division.
- The tumor’s cells feature small, finger-like projections called papillae.
- Papillae sometimes create round swirls of calcium known as psammoma bodies.
- Tumors form white or grey nodules ranging from less than 1 centimeter in size to more than 3 centimeters.
- WDPMT can develop as a solitary mass or arise in many sites. The latter has more aggressive behavior.
- Tumors are smaller than 1 centimeter in more than half of all cases.
WDPMT of the tunica vaginalis can cause scrotal swelling or the formation of testicular lumps. In one study of 22 WDPMT cases, only two patients reported to their doctors with symptoms. One patient experienced acute abdominal pain, and the other had chronic pelvic pain.
Misdiagnosis and Challenges
Doctors must collect a comprehensive tumor sample to prevent misdiagnosis. The only definitive procedure for diagnosing WDPM and other mesotheliomas is a biopsy. A biopsy collects a tissue sample for laboratory analysis.
Doctors may confuse WDPMT with several other cancers and conditions:
- Reactive mesothelial hyperplasia
- Adenomatoid tumor
- Peritoneal carcinomatosis
- Tuberculous peritonitis
- Serous papillary carcinoma of the ovary
- Serous papillary carcinoma of the peritoneum
While looking for signs of mesothelioma, doctors also look for negative markers. These markers signal it is likely not mesothelioma and is another type of cancer. For example, mesothelioma patients rarely test positive for PAX8 protein. If it’s detected, this could signal kidney cancer, thyroid cancer and cancers of the female reproductive system.
Doctors usually discover this condition during an unrelated pelvic or abdominal surgery. An imaging test, such as a CT scan, may find it. But this technique isn’t sensitive enough to detect tumors smaller than 1 centimeter in size.
Papillary Mesothelioma Treatment
Doctors have yet to reach a consensus on the most effective course of treatment.
Therapy usually involves a combination of the main types of mesothelioma treatment. These include surgery, chemotherapy and radiation therapy. Treatment options also depend on where the papillary mesothelioma tumors form.
A combination of surgery and heated chemotherapy treats abdominal cases. In a 2019 study published in Annals of Surgical Oncology, 37 of the 56 patients received this combination.
Get a Free Mesothelioma Guide
Learn about your diagnosis, top doctors and how to pay for treatment.
Prognosis and Survival Rate of Papillary Mesothelioma
The outlook is better than the prognosis of patients with most other mesothelioma cell types.
Median Survival for Well-Differentiated Papillary Mesothelioma Tumor
| WDPMT of the Pleura | WDPMT of the Peritoneum |
|---|---|
| 6 years and 2 months | 12 years |
Source:
American Journal of Surgical Pathology, 2004; Annals of Surgical Oncology, January 2019
Only 5% to 10% of malignant mesothelioma patients survive five years after diagnosis. Several patients with WDPMT have survived for decades.
The Nation's Top Mesothelioma Guide
Get Compensation You Deserve
Immunotherapy & Mesothelioma Clinical Trials
