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Written by Sean Marchese, MS, RN | Medically Reviewed By Dr. Jacques Fontaine | Edited By Walter Pacheco | Last Update: August 29, 2024
Mesothelioma clinical trials are specialized research programs that test new therapies for safety and effectiveness. Researchers use clinical trials to investigate treatment benefits, improve screening and diagnosis methods, and uncover new disease prevention methods.
Types of Mesothelioma Clinical Trials
Cancer research trials can last several months to years and go through many phases. Once recruitment starts, enrollment may be paused or canceled. During these checkpoints, researchers analyze the data. If the benefits don’t outweigh the risks of treatment, the study sponsor may suspend or terminate the study early.
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As of early 2024, more than 70 clinical trials across the U.S. are recruiting patients with mesothelioma malignancy. Our Patient Advocates at The Mesothelioma Center can help match you with clinical trials based on your diagnosis and where you live.
Active Mesothelioma Clinical Trials
This study examines whether intraperitoneal or intravenous chemotherapy given after cytoreductive surgery and HIPEC are effective treatments for peritoneal mesothelioma.
This first-in-human trial is designed to assess the safety, feasibility and potential activity of a single IV dose of SynKIR-110 administered to subjects with mesothelin-expressing advanced ovarian cancer, mesothelioma and cholangiocarcinoma.
The purpose of this study is to characterize the safety and tolerability of IAG933 in patients with mesothelioma, NF2/LATS1/LATS2 mutated tumors and tumors with functional YAP/TAZ fusions and to identify the maximum tolerated dose and/or recommended dose.
Patients in this study receive immunotherapy with standard chemotherapy in a surgical treatment plan.
This phase 2 trial compares the usual treatment alone to using immunotherapy plus the usual treatment in treating patients with peritoneal mesothelioma.
This study tests the safety of MSLN-targeted CAR T-cells to find the safest dose to give to people with malignant pleural mesothelioma. It is the first study of its kind in people.
This study examines the safety and effectiveness of poly-ICLC directly injected into malignant pleural mesothelioma during biopsy before the surgical removal.
In this study, researchers will give olaparib to mesothelioma patients who have specific changes in their DNA (known as gene mutations).
Mesothelioma clinical trials span many treatment options, including emerging treatments such as gene therapy and vaccine therapy, advancements in immunotherapy, surgical procedures and new chemotherapy approaches. Testing new combinations of techniques helps researchers find new or improved methods of treating mesothelioma that offer significant benefits without substantial risk.
You can enroll in a mesothelioma clinical trial with help from our Patient Advocates or your doctor. Mesothelioma specialists generally know which clinical trials their patients may be eligible to join. Cancer centers and clinics participating in research trials typically have staff dedicated to running clinical trials.
If you meet eligibility requirements, a research coordinator may contact you. Every mesothelioma clinical trial has specific criteria for who is eligible to participate. Some trials are only for patients who have yet to be treated or have metastatic disease, while others are for those who didn’t respond well to standard treatments.
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Along with eligibility requirements, frequent blood and imaging tests are a standard part of clinical trials. These extra precautions ensure that you’re eligible for the study and that the experimental treatment won’t cause additional harm.
After you talk to your mesothelioma doctor or a Patient Advocate, take the time to determine the trials that most appeal to you. Review and discuss the research trial information with your family. Ask your doctor as many questions as necessary to understand the risks and benefits of the trial. Once you decide, your medical team will help you begin the screening process.
Try our new clinical trials search tool to find active trials near you. Get help enrolling today.
Help Me Find a TrialMesothelioma patients may benefit from new emerging treatments or advanced approaches tested in clinical trials. Trials may help improve their prognosis and quality of life. These therapies may not be available through standard treatment options, making clinical trials a valuable resource for mesothelioma patients.
I want to be as helpful as I can. Being in a clinical trial has allowed me to do that, providing information to researchers about therapies that could help patients in the future. Sure, I was hoping it could help me, but it’s also rewarding when you know you’re helping others, which is what a clinical trial does.
Experimental drugs, for example, can provide a targeted approach to treating cancer. These drugs target specific proteins or pathways in cancer cells, attacking specific pathways involved in tumor growth and spread.
Clinical trials may offer patients the chance to receive a combination of experimental therapies. Some of these combinations have proven effective in early studies. This approach can be particularly beneficial for mesothelioma patients, as a multimodal therapeutic approach often yields the best outcomes when treating this cancer.
Ron Green spent almost a year in a clinical trial for the immunotherapy drug Keytruda. It’s shown impressive effectiveness, but only for a small percentage of patients. Green was one of the fortunate few. Some time after the trial, scans showed tumor regrowth despite the radiation therapy. He was referred to another trial for chemotherapy with anetumab ravtansine, which shrank his tumors.
Sometimes, a clinical trial results in a breakthrough, which can change the way doctors approach cancer treatment. For example, research studies led to FDA approval of the first mesothelioma chemotherapy option and the more recent Tumor-Treating Fields. The trial results that led to FDA approval showed improved overall survival over 6 months.
Although there is no cure for mesothelioma, successful clinical trial therapies improve survival rates and quality of life. Many mesothelioma trials struggle to get enough participants to test a new drug or treatment. Joining a trial helps researchers get closer to developing a cure for mesothelioma.
Clinical trials always involve certain risks. The experimental treatment may not be as effective as anticipated, and you could experience unexpected side effects that harm your health.
A mesothelioma clinical trial can last weeks, months or years, depending on the trial’s goal, the number of patients involved and the results. During this time, doctors and researchers work to maximize benefits and minimize risks. Clinical trials go through multiple phases to ensure a new treatment is safe and effective for a large population.
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Get Help NowGetting answers to your questions to help you understand the details and purpose of the trial before enrolling is critical. Take notes during your meeting with your doctor.
Don’t be afraid to ask any questions you or your loved ones may have. Follow up with your doctor’s office or clinical trial staff if you think of other questions or need clarification to help you decide if participating in a clinical trial is best for you.
You can learn more about mesothelioma clinical trials from your doctor and at ClinicalTrials.gov. A Patient Advocate can also help you find available clinical trials that match your specific diagnosis.
Many clinical trials cover all or part of the therapies used in clinical trials, but each trial varies. Health insurance often covers specific treatments, such as traditional chemotherapy.
Placebos are not common, but they are sometimes used in cancer trials in combination with conventional treatment, experimental treatments or when no conventional treatment exists. Researchers are never allowed to withhold necessary medical care intentionally. Participating in a clinical trial will benefit you with high-quality medical care.
Yes, it’s always a patient’s right to withdraw from a clinical trial. Patients should provide “written informed consent” before participating in a clinical trial. The trial documentation should describe the right to cancel and how to withdraw. It may be most helpful for research if someone who withdraws from the trial treatment and tests continues to allow follow-up, for example, of side effects and length of life.
Answered By: Anna Nowak, internationally renowned asbestos researcher and mesothelioma advocate
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Marchese, S. (2024, August 29). Mesothelioma Clinical Trials. Asbestos.com. Retrieved October 9, 2024, from https://www.asbestos.com/treatment/clinical-trials/
Marchese, Sean. "Mesothelioma Clinical Trials." Asbestos.com, 29 Aug 2024, https://www.asbestos.com/treatment/clinical-trials/.
Marchese, Sean. "Mesothelioma Clinical Trials." Asbestos.com. Last modified August 29, 2024. https://www.asbestos.com/treatment/clinical-trials/.
A medical doctor who specializes in mesothelioma or cancer treatment reviewed the content on this page to ensure it meets current medical standards and accuracy.
Please read our editorial guidelines to learn more about our content creation and review process.
Dr. Jacques Fontaine is a thoracic surgeon at Moffitt Cancer Center in Tampa, Florida, where he heads up the Mesothelioma Research and Treatment Center. He specializes in minimally invasive robotic surgery and aggressive surgeries for mesothelioma.
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