What Is Malignant Peritoneal Mesothelioma?

Malignant peritoneal mesothelioma is a rare and aggressive cancer that forms in the abdomen. It’s also known as abdominal mesothelioma or mesothelioma of the stomach.

The primary proven cause of malignant peritoneal mesothelioma is asbestos exposure. Asbestos fibers become lodged in the abdomen when inhaled or ingested.

About 300 to 500 peritoneal mesothelioma cases are diagnosed each year in the U.S. The incidence is equal among women and men. This contrasts with pleural mesothelioma, which develops in the lungs and is far more common in men.

An even rarer form of peritoneal mesothelioma cancer can develop in the omentum. This abdominal lining covers the stomach and other organs.

“The first thing I like to tell [peritoneal mesothelioma patients] is that they certainly do have options. With good treatment that we use now, that median survival could actually be several years.”
Dr. W. Charles Conway
Peritoneal mesothelioma specialist

What Are the Symptoms of Peritoneal Mesothelioma Cancer?

Symptoms of peritoneal mesothelioma include bloating, pain around the abdomen, constipation and diarrhea. Symptoms do not develop in many patients until this cancer reaches an advanced stage.

Peritoneal Mesothelioma Symptoms Include:

  • Abdominal pain
  • Abdominal swelling (ascites)
  • Night sweats
  • Nausea and vomiting
  • Fever
  • Unexplained weight loss
  • Fatigue
  • Diarrhea
  • Constipation
  • Loss of appetite
  • Bowel or urinary problems

These symptoms tend to mimic many other abdominal disorders. An accurate diagnosis often requires a mesothelioma specialist and a biopsy sample. 

Anyone who was exposed to asbestos should discuss their history with their doctor. Mesothelioma screenings, such as regular imaging tests, may be recommended. Your doctor can watch for any new or worsening symptoms.

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What Causes Peritoneal Mesothelioma?

The primary cause of malignant peritoneal mesothelioma is exposure to asbestos fibers. If the thin fibers are ingested, they can travel through the bloodstream to the abdomen. This causes inflammation, which may develop into cancer after many years.

Process of Peritoneal Mesothelioma Development

Peritoneal mesothelioma develops over a long period of time. The trapped asbestos fibers cause inflammation and irritation, damaging and degrading DNA. 

Damaged DNA can lead to abnormal and unregulated cell growth. These errors cause tumors to form, and the tumors can grow and spread to other areas of the body.

How Tumors Develop
  • Inhaled or swallowed asbestos fibers pass through the bloodstream and digestive system.
  • Asbestos fibers reach the lymphatic system and travel to the peritoneum.
  • Fibers become stuck in the peritoneum, irritating cells and damaging DNA for years.
  • The irritated cells become inflamed, form scar tissue and thicken the peritoneal lining.
  • Years of inflammation and scar tissue formation cause excess abdominal fluid buildup.
  • After prolonged damage, malignant tumors begin to form on the diseased peritoneum.
  • As tumors grow, they put pressure on vital organs and can spread to form new tumors.
peritoneal mesothelioma development.
How peritoneal mesothelioma develops

Research on malignant peritoneal mesothelioma is still ongoing. This disease is rare and connected to toxic asbestos exposure.

How Is Peritoneal Mesothelioma Diagnosed?

Peritoneal mesothelioma is diagnosed with a biopsy. The biopsy is the only way to confirm mesothelioma versus other diseases. Imaging scans and blood tests play a role in diagnosing the type and stage of the cancer.

  • Imaging scans show the size and location of tumors.
  • Blood tests reveal certain biomarkers associated with cancer.
  • Biopsies show what kind of cancerous cells are present.

Biopsies are samples of tumor tissue that doctors examine under a microscope in a lab. Pathologists, perform tests on the biopsy sample to reveal the kinds of cancerous cells within the tumors. They then summarize the results in a pathology report.

An examination of medical history, occupational history and physical condition aids in diagnosis.

Diagnosing Peritoneal Mesothelioma Cell Types

The pathology report contains which cellular subtype of peritoneal mesothelioma you have. Diagnosing the cell type is important because it helps doctors determine which therapies may work best for you.

Common Cell Types

  • Epithelioid Cells: This is the most common, making up 75% of cases.
  • Biphasic Cells: Biphasic is the second-most common type, making up 25% of cases. It is a mix of epithelioid and sarcomatoid cells.

Epithelioid peritoneal mesothelioma can grow in four different patterns. They include papillary, tubular, diffuse and deciduous. Papillary is the most common. It often appears alongside the others.

Pure sarcomatoid tumors are uncommon in malignant peritoneal mesothelioma. Specialists have only diagnosed about 30 cases of this variant since 2006. Sarcomatoid cells usually occur alongside epithelioid cells to form the biphasic subtype.

Rare Cell Types

  • Well-Differentiated Papillary Mesothelioma: This variant is uncommon, with less potential for malignancy, and typically presents in younger women.
  • Multicystic Mesothelioma: This subtype often recurs after surgery and does not have a definitive link to asbestos exposure.
  • Desmoplastic Mesothelioma: This tumor type can present as nodules or a mass-like peritoneal thickening, ascites or lymph node disease.
  • Lymphohistiocytoid Mesothelioma: A dense lymphatic infiltrate characterizes this variant.
  • Pure Sarcomatoid Mesothelioma: The rarest and most lethal form of peritoneal mesothelioma, this subtype is associated with aggressive metastasis.

Omental mesothelioma is a rare variant that occurs in the omentum. It is a part of the peritoneum surrounding the stomach and other abdominal organs. The layer of fatty tissue plays a role in immune function and metabolism.

Misdiagnosis of Peritoneal Mesothelioma

Doctors lack experience with the disease and misdiagnose it as more common illnesses. Peritoneal mesothelioma misdiagnosis can delay proper treatment.

The best way to get a diagnosis is to schedule an appointment with a mesothelioma specialist. Peritoneal specialists have the knowledge and tools needed to make a precise diagnosis.

Stages of Peritoneal Mesothelioma

There is no official staging system for peritoneal mesothelioma. But doctors have used the TNM system to define three peritoneal mesothelioma stages.

Illustration of staged progression of peritoneal mesothelioma. Early-stage tumors are localized in one area of the peritoneal lining. Mid-stage peritoneal mesothelioma may be more extensive and involve deeper tissues or lymph nodes. Late-stage cancer has spread to distant structures in the abdomen.
The stages of tumor progression in peritoneal mesothelioma.

3 Stages of Peritoneal Mesothelioma

  • Stage 1: Cancerous tissue is minimal, tumors are only within the abdominal lining, and lymph nodes are free of cancer.
  • Stage 2: Cancerous tissue is moderate, and tumors have not spread outside the lining or into lymph nodes.
  • Stage 3: Cancerous tissue is more extensive, and tumors may have spread outside the peritoneal lining or into lymph nodes.

Many doctors consider stage 4 to involve extensive tumors that have spread to distant sites throughout the body.

Peritoneal Cancer Index

The Peritoneal Cancer Index is a diagnostic tool doctors use to assess tumor location and spread in the abdomen. It helps them determine the approximate mesothelioma stage and appropriate treatments.

This index divides the abdomen into 13 parts. Doctors assign a number (1 to 3) to each area based on the most sizable tumor in that area. The Peritoneal Cancer Index score is the sum of the individual scores from the 13 regions. A patient’s maximum score is 39 (13 times three).

Lower index scores mean the patient may qualify for surgery. Index scores above 20 indicate cancer has spread too far and the patient likely won’t respond well to surgery.

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Peritoneal Mesothelioma Treatment Options

Heated Intraperitoneal chemotherapy (HIPEC) treatment for peritoneal mesothelioma
HIPEC treatment process

The most effective peritoneal mesothelioma treatment option is cytoreductive surgery with heated chemotherapy. The latter is known as hyperthermic intraperitoneal chemotherapy or HIPEC.

More than 60% of patients are ineligible for surgery with heated chemotherapy. Surgery can take several hours. It may involve removing large portions of the intestines or whole organs. Chemotherapy alone is the most used treatment.


Patients who don’t qualify for surgery with HIPEC can receive systemic chemotherapy. Some patients receive only intraperitoneal chemotherapy. 

Chemotherapy drugs can shrink peritoneal mesothelioma tumors and slow the growth and spread of cancer. Effective drugs for peritoneal mesothelioma include pemetrexed, cisplatin, carboplatin and gemcitabine.

U.S. Navy pilot and peritoneal mesothelioma survivor Jim Madaris decided to seek out the HIPEC procedure after his diagnosis in 2013. The surgery took 14 hours and removed his gallbladder, spleen and parts of his intestine. Madaris’ life was extended by four years, allowing him to find joy in the little things and see his youngest child graduate high school.

“I’m fortunate. I’ve lasted four times longer than my first doctor expected. Even if something happens tomorrow, we’re still calling it a victory.”
Jim Madaris
Diagnosed with peritoneal mesothelioma
Cytoreductive surgery for peritoneal mesothelioma
Cytoreductive surgery targets multiple sites in the abdomen.

Cytoreductive Surgery with Heated Chemotherapy

Cytoreductive surgery is used during a peritonectomy. It attempts to remove as much cancer as possible. Heated chemotherapy is applied locally to the abdomen before the surgery ends. Doctors only perform this procedure on a case-by-case basis.

A 2022 study in the Journal of Clinical Haematology reported that more than 80% of the patients who underwent this procedure lived five years or longer.

Palliative Treatment Options

Many peritoneal patients receive palliative care. It controls symptoms and improves the quality of life for patients. For example, a paracentesis procedure drains excess fluid from the abdomen to lessen pain.

A palliative care specialist prescribes medications to control pain and side effects. They may refer patients to physical or occupational therapy or recommend complementary therapies.

Top Peritoneal Doctors

Dr. Paul H. Sugarbaker
Peritoneal Specialist
  • Speciality: Surgical Oncology
  • Expertise: Cytoreductive Surgery HIPEC
Dr. W. Charles Conway
Peritoneal Specialist
  • Speciality: Peritoneal Surface Malignancies
  • Expertise: Cytoreductive Surgery HIPEC
  • Location: Santa Barbara, California
Dr. J.F. Pingpank Jr.
Peritoneal Specialist
  • Speciality: Surgical Oncology
  • Expertise: HIPEC Research
  • Location: Pittsburgh, Pennsylvania
Dr. Sophie Dessureault
Peritoneal Specialist
  • Speciality: Surgery
  • Expertise: Cytoreductive Surgery HIPEC
  • Location: Tampa, Florida
Dr. Mecker Moller
Peritoneal Specialist
  • Speciality: Surgical Oncology
  • Expertise: Cytoreductive Surgery HIPEC
  • Location: Miami, Florida
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Peritoneal Mesothelioma Life Expectancy and Prognosis

The life expectancy for peritoneal mesothelioma is about 12 months with chemotherapy alone. Surgery can improve a patient’s prognosis significantly. More than 50% of peritoneal patients who undergo surgery with HIPEC live more than five years.

The prognosis for peritoneal mesothelioma is generally poor for patients who don’t qualify for surgery. The median survival of peritoneal mesothelioma patients who do not undergo any treatment is six months.

Survivor Insight
Alexis was diagnosed with peritoneal mesothelioma in 2007, had major surgery that removed part of her diaphragm, yet kept her wedding plans in place. She refuses to let mesothelioma get in the way of the life she and her husband have built. “It’s kind of cool now to hear people say, ‘You don’t look or act sick.’”

Alexis K.

Peritoneal mesothelioma survivor

Women with malignant peritoneal mesothelioma tend to live longer than men. A 2020 study in the American Journal of Surgical Pathology published the report. About 77.8% of women treated with cytoreductive surgery and heated chemotherapy survived longer than five years.  

When averaging short- and long-term survival, women live approximately 13 months on average, and men live roughly six months.

Factors Affecting Prognosis

Prognostic factors include details about the patient’s cancer and health. Elected treatments also affect a patient’s prognosis.

Patients with epithelial cells have a longer life expectancy than other cell types. Epithelial cells tend to respond better to treatments such as chemotherapy.

  • Stage at diagnosis
  • Cell type
  • Tumor grade (how fast it grows)
  • Gender
  • Genetic mutations
  • Treatments selected

The tumor’s grade also impacts prognosis. Tumor grade indicates how quickly tumors are likely to grow and spread, based upon how abnormal the cells appear.

Chemotherapy Survival Rates

Systemic (whole-body) chemotherapy combined with cisplatin and pemetrexed has the following benefits:

  • A response rate of about 30%
  • Average progression-free survival around 11.5 months
  • Median survival around 13 months

Chemotherapy delivered directly to the peritoneum without surgery has a higher response rate of 47%. When combined with heated chemotherapy given during surgery, the response rate is 84.6%

Is There a Cure for Peritoneal Mesothelioma?

There is no cure for peritoneal mesothelioma or any other type of mesothelioma. But those eligible for surgery and HIPEC live longer than five years.

Some patients may be eligible for repeat surgery with heated chemotherapy if a recurrence happens.

In 2017, Dr. Paul Sugarbaker reported improved survival among patients who received early post-operative chemotherapy and long-term chemotherapy after cytoreductive surgery with heated chemotherapy.

Surgery with HIPEC, post-operative chemotherapy and long-term chemotherapy worked best. About 75% of these patients lived longer than five years.

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“They tell you how HIPEC affects you physically, but no one tells you how it affects you mentally. To be honest, it was a bit rough, but I’m glad I got through it.”
Tamron Little
Peritoneal Mesothelioma Survivor

Feelings of depression or loneliness are common among peritoneal mesothelioma patients. Support services such as counselors and support groups are available. Talking to a counselor or joining a support group can help improve quality of life.

The Mesothelioma Center hosts an online support group. It connects patients and families with one another and offers professional guidance. Dana Nolan, MS, LMHC, is a licensed counselor and serves as the moderator. Patient advocate and registered nurse Karen Selby is also available to answer medical questions.

Common Questions About Peritoneal Mesothelioma

What are the symptoms of abdominal mesothelioma?

The symptoms of peritoneal mesothelioma include abdominal pain, abdominal swelling or distension, diarrhea or constipation, weight loss and fatigue. Other symptoms may develop as the disease progresses, such as fever and night sweats.

Where can peritoneal mesothelioma spread?

Peritoneal mesothelioma can metastasize to the lymph nodes and throughout the abdominal cavity, including the liver and stomach. At later cancer stages it can spread to more distant areas in the body such as the lungs, pleural cavity, intestines, spleen and kidneys.

How fast does peritoneal mesothelioma spread?

Peritoneal mesothelioma spreads fairly quickly. Exact rates of spread vary individually and are affected by the cell type of the tumors. Patients who do not undergo treatment have a median survival of six months. This means peritoneal mesothelioma spreads significantly within half a year without treatment.

Is peritoneal mesothelioma curable?

Malignant peritoneal mesothelioma is incurable at all four stages. Clinical trials search for a cure. They test new treatments, including immunotherapy and multimodal therapy.

How long do peritoneal mesothelioma patients live?

Peritoneal mesothelioma patients have a life expectancy of about one year. Survival is better for patients who qualify for surgery with heated chemotherapy. Half of the patients who qualify for this procedure live at least five years.