Factors Affecting Mesothelioma Life Expectancy
A person’s life expectancy with mesothelioma is affected by many factors you cannot control, including the stage of mesothelioma and your age at time of diagnosis. You can control some factors such as undergoing mesothelioma treatments, participating in clinical trials and improving your overall health and lifestyle choices.
The primary factors affecting mesothelioma life expectancy include:
The cancer’s stage, type and the cells in the tumor
Your gender, age, overall health, lifestyle and blood characteristics
The treatments and clinical trials you try
Your life expectancy is an important part of your prognosis, which is the overall outlook of how mesothelioma will affect your body and life span.
The stage of mesothelioma at diagnosis is the most important factor determining life expectancy.
Staging is a medical designation to describe the extent of cancer progression at the time of diagnosis. It is measured from 1 to 4. As stage number increases, life expectancy decreases, and prognosis worsens.
|Stage 1||22.2 months|
|Stage 2||20 months|
|Stage 3||17.9 months|
|Stage 4||14.9 months|
Source: Journal of Thoracic Oncology, 2016
Mesothelioma Tumor Type and Location
Asbestos cancer life expectancy varies in surgical patients diagnosed with pleural mesothelioma and peritoneal mesothelioma.
A 2017 analysis of 442 patients with mesothelioma showed median survival was nine months among pleural mesothelioma patients and 18 months in patients with peritoneal mesothelioma. The study included patients who did and didn’t receive treatment.
In this review, surgery, systemic therapy and particularly the combination of the two treatments was associated with better all-cause survival.
Pleural Mesothelioma Life Expectancy
Research shows people with pleural mesothelioma, which occurs in the membrane surrounding the lungs, live an average of three years with surgery. Nearly 75% of all pleural mesothelioma patients live one year after their diagnosis. Only 23% survive for three or more years.
Peritoneal Mesothelioma Life Expectancy
With aggressive treatment, patients with peritoneal mesothelioma, which occurs in the lining of the abdomen, may live five or more years after receiving their cancer diagnosis.
Peritoneal mesothelioma is easier to treat with surgery than pleural mesothelioma. Surgery increases peritoneal mesothelioma life expectancy more than it does for pleural patients.
Life Expectancy for Other Mesothelioma Types
The rarest types of mesothelioma affect the membranes around the heart (pericardial mesothelioma) and the testes (testicular mesothelioma).
Median survival for pericardial mesothelioma is around six to 10 months. The life span for people with testicular mesothelioma is at least two years on average.
Mesothelioma Cell Type
Mesothelioma patients with epithelial tumors, also called epithelioid cell type, live 200 days longer, on average, than patients with biphasic or sarcomatoid disease.
Sarcomatoid mesothelioma tends to be more aggressive and less responsive to treatment.
Younger people tend to live longer with mesothelioma than older patients. Younger mesothelioma patients are often healthier, making them eligible for more treatments and clinical trials than older patients.
For people diagnosed earlier in life, these differences lead to longer life expectancy with mesothelioma.
A 2019 study using data from the National Cancer Database reviewed 4,526 newly diagnosed nonmetastatic malignant pleural mesothelioma patients 80 years and older.
In the study:
Only 2% received surgery and chemotherapy
Most patients (63%) received no treatment
Median survival for the observed (no treatment) group was 4.1 months
Median survival for the surgery and chemotherapy group was 12.2 months
Patients who only received chemotherapy survived 9.5 months on average
For the 8% of patients who had surgery, 28.5% died within 90 days
While surgery can provide improved life expectancy in older mesothelioma patients, the risks of this aggressive approach are significant.
Jim Madaris Pleural mesothelioma survivor diagnosed in 2013
“I’m fortunate. I’ve lasted four times longer than my first doctor expected. Even if something happens tomorrow, we’re still calling it a victory.”
Women are much less likely to be diagnosed with mesothelioma, by an approximate 4-to-1 ratio. Women with epithelial mesothelioma also live longer, on average, compared with men with the same mesothelioma cell type.
The National Cancer Institute reports 15.6% of women with mesothelioma survive for five years. Only 8.8% of men live that long.
One reason women may live longer is they typically have had less intense exposure to asbestos, the primary cause of mesothelioma. This may lead to less aggressive tumors.
Another reason is the type of mesothelioma that is diagnosed. Women are more likely to be diagnosed with peritoneal mesothelioma, which carries a better life expectancy and prognosis. Most men are diagnosed with pleural mesothelioma, which is tougher to treat and has a worse life expectancy compared to peritoneal.
Overall Health and Lifestyle Choices
Having other chronic conditions, such as asbestosis, chronic bronchitis, diabetes or heart disease, can decrease life expectancy after a mesothelioma diagnosis.
Tobacco use also can impact survival after mesothelioma.
Smoking does not cause mesothelioma, but it can worsen overall health in people with the disease, leading to shorter survival after diagnosis.
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Improving Life Expectancy with Treatment
Anti-cancer therapies improve life expectancy. Median life expectancy for stage 4 mesothelioma is approximately a year with treatment versus seven months without treatment.
Patients with stage 1 or stage 2 disease may be eligible to receive multimodal therapy combining surgery, chemotherapy and radiation therapy.
Younger, healthier, stage 3 patients with the epithelial or biphasic cell type may qualify for combination treatments, too.
Surgery may not be an option for some people with late-stage mesothelioma, but if your health is good enough, you still may be eligible for this treatment approach.
A 2017 study found even for patients with advanced mesothelioma, pleurectomy and decortication surgery led to an average survival of nearly three years.
Clinical Trials and Emerging Treatments
Your best chance for improving mesothelioma life expectancy may come from clinical trials that test experimental treatments.
Immunotherapy and photodynamic therapy have shown promise for extending the life expectancy of mesothelioma patients. Researchers also are studying gene therapy and other targeted treatments.
Your oncologist can help find clinical trials tailored just for you.
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Mesothelioma Life Expectancy Without Treatment
The average pleural mesothelioma life expectancy is about eight months without treatment.
Peritoneal mesothelioma responds well to treatment, often better than pleural disease. Peritoneal patients who qualify for surgery and hyperthermic intraperitoneal chemotherapy (HIPEC) have a 50% chance of living longer than five years.
However, peritoneal mesothelioma cancer progresses quickly without therapy. Average peritoneal life expectancy without treatment is approximately six months.
Improving Life Expectancy
A mesothelioma diagnosis is challenging, but many people lived longer by taking active steps to improve their health.
Increase Activity Level & Fitness
“Performance status” is a technical term that refers to the activity level and general fitness of a patient. Nearly all studies on performance status in mesothelioma patients show a significant effect on survival.
The more active and fit you are, the more likely your body will be able to withstand and recover from aggressive cancer treatments.
Improve Your Nutrition
Cancer patients who are better nourished have longer survival. Eating right helps your body recover from aggressive treatments and maintain good immune function.
You may have heard or read about diets for mesothelioma patients. If you want to know more about these diets, ask your doctor for a referral to see a cancer dietitian.
In general, an appropriate mesothelioma diet and good nutrition will provide plenty of protein to support recovery and enough calories to prevent weight loss.
Consider Complementary Medicine
Complementary medicine refers to other approaches used in combination with conventional cancer treatment. This strategy is also called integrative medicine or integrative oncology. Examples include acupuncture, meditation, herbal medicine and yoga. These therapies may reduce stress and pain and improve quality of life.
You should always consult your doctor before starting any integrative therapy to avoid drug interactions and negative treatment consequences.
10 Cited Article Sources
The sources on all content featured in The Mesothelioma Center at Asbestos.com include medical and scientific studies, peer-reviewed studies and other research documents from reputable organizations.
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Friedberg, J.S. et al. (2017, March). Extended Pleurectomy-Decortication-Based Treatment for Advanced Stage Epithelial Mesothelioma Yielding a Median Survival of Nearly Three Years. doi: 10.1016/j.athoracsur.2016.08.071
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Last Modified January 10, 2020