Last modified: June 21, 2021
What Is the Life Expectancy for Mesothelioma?
The life expectancy for mesothelioma patients is around one year, but it varies from person to person based on several factors, including type of mesothelioma, but cancer stage is the most impactful. Tumor size and the extent of their spread determines stages, which can help mesothelioma specialists plan the best course of treatment and evaluate a patient’s prognosis.
Doctors use the terms life expectancy, life span and survival rate to explain a patient’s prognosis. These terms are similar, but not interchangeable. It is helpful to understand what they mean for your mesothelioma prognosis.
- Prognosis is an overall outlook of how mesothelioma will affect your health.
- Life expectancy and lifespan describe how long someone is estimated to live with mesothelioma.
- Survival rate is the percentage of patients who live five years after diagnosis. It may also be measured at one and two years after diagnosis.
- Average and median refer to different survival rate figures. The average is reached by dividing total survival time by the number of patients in a study. The median is the middle figure that separates the highest survival time from the lowest.
Keytruda has worked like a charm for me. There have been absolutely no side effects. For me, it’s the magic bullet. I just feel like I’ve been blessed with what I’ve been given, and that’s extra time.Barbara LappalaPleural Mesothelioma Survivor
Life expectancy following a mesothelioma diagnosis greatly depends on the cancer’s stage, cell type and location where it originally developed. A patient’s age, gender and overall health also play a role in life expectancy.
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Life Expectancy for Different Mesothelioma Types
The different types of mesotheliomas are defined by the part of the body where they originate. This has a big impact on life expectancy because certain vital organs, such as the heart, are affected by cancer growth.
Pleural Mesothelioma Life Expectancy
Research shows some people with pleural mesothelioma, which occurs in the membrane surrounding the lungs, live an average of three years with surgery.
Nearly 75% of all pleural mesothelioma patients live one year after their diagnosis. Only 23% survive for three or more years.
Peritoneal Mesothelioma Life Expectancy
With aggressive treatment, about half of patients with peritoneal mesothelioma, which occurs in the lining of the abdomen, live five or more years after receiving their cancer diagnosis.
Peritoneal mesothelioma is easier to treat with surgery than pleural mesothelioma. Surgery increases peritoneal mesothelioma life expectancy more than it does for pleural patients.
Pericardial and Testicular Mesothelioma Life Expectancy
The rarest types of mesothelioma affect the membranes around the heart (pericardial mesothelioma) and the testes (testicular mesothelioma).
Median survival for pericardial mesothelioma is around six to 10 months. The lifespan for people with testicular mesothelioma is at least two years on average.
Key Factors of Mesothelioma Life Expectancy
A person’s life expectancy with mesothelioma is affected by many factors you cannot control, including the stage of mesothelioma and your age at the time of diagnosis. Some factors can be controlled, such as undergoing mesothelioma treatments, participating in clinical trials and improving your overall health and lifestyle choices.
PRIMARY FACTORS AFFECTING MESOTHELIOMA LIFE EXPECTANCY
- The cancer’s stage, type and the cells within the tumor
- Gender, age, overall health, lifestyle and blood characteristics
- Choice of treatments and clinical trials
Your life expectancy is an important part of your prognosis, which is the overall outlook of how mesothelioma will affect your body and life span.
The stage of mesothelioma at diagnosis is the most important factor determining life expectancy.
Staging is a medical designation to describe the extent of cancer progression at the time of diagnosis. Cancers are usually staged as 1-4. As the stage number increases, life expectancy decreases, and prognosis worsens. Prognosis worsens because the cancer is growing into vital organs.
Mesothelioma Cell Type
Mesothelioma patients with epithelial tumors, also called epithelioid cell type, live 200 days longer, on average, than patients with biphasic or sarcomatoid disease. That’s because epithelial cells respond better to treatment.
Sarcomatoid mesothelioma tends to be more aggressive and less responsive to treatment.
Younger people tend to live longer with mesothelioma than older patients. Younger mesothelioma patients are often healthier, making them eligible for more treatments and clinical trials than older patients. For people diagnosed earlier in life, these differences lead to longer life expectancy with mesothelioma.
A 2019 study using data from the National Cancer Database reviewed 4,526 newly diagnosed nonmetastatic malignant pleural mesothelioma patients 80 years and older. In the study only 2% received surgery and chemotherapy and most patients (63%) received no treatment. Median survival for the observed (no treatment) group was 4.1 months.
Median survival for the surgery and chemotherapy group was 12.2 months. Patients who only received chemotherapy survived 9.5 months on average. For the 8% of patients who had surgery, 28.5% died within 90 days.
While surgery can provide improved life expectancy in older mesothelioma patients, the risks of this aggressive approach are significant.
Women are much less likely to be diagnosed with mesothelioma, by an approximate 4-to-1 ratio. Women with epithelial mesothelioma also live longer, on average, compared to men with the same mesothelioma cell type.
One reason women may live longer is they typically have had less intense exposure to asbestos, the primary cause of mesothelioma. This may lead to less aggressive tumors.
Another reason is the type of mesothelioma. Women are more likely to be diagnosed with peritoneal mesothelioma, which carries a better life expectancy and prognosis. Most men are diagnosed with pleural mesothelioma, which is tougher to treat and has a worse life expectancy compared with peritoneal mesothelioma.
A 2020 study published in American Journal of Surgical Pathology reported a five-year survival rate of 77.8% among women with peritoneal mesothelioma who underwent cytoreductive surgery with heated chemotherapy. On average, about 50% of men who undergo the procedure survive that long with the disease.
Overall Health and Lifestyle Choices
Having other chronic conditions, such as asbestosis, chronic bronchitis and emphysema (COPD), obesity, diabetes or heart disease, can decrease life expectancy after a mesothelioma diagnosis.
Tobacco use also can impact survival after mesothelioma. Smoking does not cause mesothelioma, but it can worsen overall health in people with the disease, leading to shorter survival after diagnosis.
Improving Life Expectancy with Treatment
Anti-cancer therapies improve life expectancy. Average life expectancy for stage 4 mesothelioma is approximately a year with treatment versus seven months without treatment.
For someone just diagnosed, you’ll feel all alone at first. A real shock. Just don’t give up. Whatever treatment the experts say you need, just do it. For me, it was never in doubt. I had so much to live for.Chris GibneyPleural Mesothelioma Survivor
Patients with stage 1 or stage 2 disease may be eligible to receive multimodal therapy combining surgery, chemotherapy and radiation therapy.
Younger, healthier, stage 3 patients with the epithelial or biphasic cell type may also qualify for combination treatments.
Late-stage treatment options include chemotherapy, radiation therapy, immunotherapy and Tumor Treating Fields therapy. Surgery may not be an option for some people with late-stage mesothelioma, but if your health is good enough, you still may be eligible for this treatment approach.
Clinical Trials and Emerging Treatment
For many patients, improving mesothelioma life expectancy involves participating in clinical trials that test experimental treatments.
Immunotherapy and photodynamic therapy have shown promise for extending the life expectancy of mesothelioma patients. Researchers also are studying gene therapy and other targeted treatments.
Your oncologist can help find clinical trials tailored just for you.
Mesothelioma Life Expectancy Without Treatment
The average pleural mesothelioma life expectancy without treatment is about eight months.
Peritoneal mesothelioma responds well to treatment, often better than pleural disease. Peritoneal patients who qualify for surgery and hyperthermic intraperitoneal chemotherapy, also known as HIPEC, have a 50% chance of living longer than five years. However, peritoneal mesothelioma cancer progresses quickly without therapy. Average peritoneal life expectancy without treatment is approximately six months.
Deciding to undergo treatment is a difficult decision for many people with mesothelioma. Each person has a right to determine whether they believe the potential benefits of treatment outweigh the risks. Consider talking with your family and closest loved ones to help you decide whether treatment is right for you and which treatments you are comfortable with. There are no guarantees, but electing treatment is your best chance at living longer with mesothelioma.
|Type of Mesothelioma||Survival With Aggressive Treatment||Survival With Aggressive Treatment||Survival With Aggressive Treatment|
|Pleural Mesothelioma||3 years||1 year||8 months|
|Peritoneal Mesothelioma||5 years||1 year||6 months|
Improving Life Span
A mesothelioma diagnosis is challenging, but many people live longer by taking active steps to improve their health.
Increase Activity Level & Fitness
“Performance status” is a technical term that refers to the activity level and general fitness of a patient. Nearly all studies on performance status in mesothelioma patients show a significant effect on survival.
The more active and fit you are, the more likely your body will be able to withstand and recover from aggressive cancer treatments.
Cancer patients who are better nourished experience longer survival. Eating right helps your body recover from aggressive treatments and maintain good immune function.
You may have heard or read about diets for mesothelioma patients. If you want to know more about these diets, ask your doctor for a referral to a cancer dietitian.
In general, an appropriate mesothelioma diet and good nutrition will provide plenty of protein to support recovery and enough calories to prevent weight loss.
Complementary medicine refers to other approaches used in combination with conventional cancer treatment. This strategy is also called integrative medicine or integrative oncology. Examples include acupuncture, meditation, herbal medicine, yoga and support groups. These therapies may reduce stress and pain and improve quality of life.
You should always consult your doctor before starting any integrative therapy to avoid drug interactions and negative treatment consequences.
Common Questions About Mesothelioma Life Expectancy
- What is the difference between life expectancy, survival rate and prognosis?
Life expectancy is the number of months or years a patient can expect to live with their current diagnosis. The survival rates for mesothelioma are the percentages of people who live beyond a certain point after diagnosis. For example, 12% of patients live for five years.
The mesothelioma prognosis for a patient is the doctor’s description of their outlook based on response to treatment and the prospect of recovery. Doctors typically describe a prognosis in terms such as “favorable” or “poor.”
- What happens in the final stages of mesothelioma?
In end-stage mesothelioma, symptoms are more severe and treatment is limited. Stage 3 mesothelioma patients experience difficulty breathing, chest pain, weight loss and fevers. Because of significant tumor involvement, patients are ineligible for surgery and receive chemotherapy to slow tumor growth.
Stage 4 mesothelioma, the final stage, involves tumors on the liver, spine, brain, kidneys or other organs. Symptoms are extreme and respiratory or cardiac failure is the leading causes of death. Chemotherapy can improve symptoms and extend life expectancy by several months. Palliative care in the end stage reduces pain and other symptoms for comfort.
- How can life expectancy for mesothelioma be improved?
Mesothelioma treatment options, such as chemotherapy and radiation, improve life expectancy by reducing tumor size and preventing the growth and spread of cancer.
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