How Long Do Mesothelioma Patients Live Without Treatment?

Patients in stage 1a mesothelioma live an average of two years without treatment. Those with stage 4 mesothelioma live an average of six to eight months without treatment. In contrast, surgery can extend survival by years.

Treatment options for peritoneal mesothelioma can extend survival even longer. Many who receive surgery and heated chemo live longer than five years. About a third of people with a malignant mesothelioma tumor choose not to receive anti-cancer treatment.

Comparison between stage 1 and stage 4 pleural mesothelioma

Survival varies on several other factors. These include tumor grade, general health, age and gender. Another factor is whether the patient elects palliative care. These options can control symptoms and improve quality of life.

What Happens if Mesothelioma Is Left Untreated?

Untreated mesothelioma grows and spreads faster than with treatment. The rate of growth depends on the cancer stage and location.

Some patients have a slower form of cancer, but most mesothelioma cases are rapid. It’s also likely a slower cancer can enlarge and spread without a change in symptoms.

Certain factors may improve prognosis. Younger women with an epithelial cell type tend to live longer. Good general health can also improve prognosis. Regardless, survival is worse for most people who turn down treatment.

Growing Tumors Affect Symptoms

Without treatment, pleural mesothelioma tumors spread from the lung lining to the rest of the chest cavity.

Growing tumors will cause symptoms that affect how patients feel. As they grow, chest pain, shortness of breath and coughing often worsen.

Peritoneal mesothelioma can also progress without treatment. Symptoms in the abdomen will likely get worse. These include abdominal pain, swelling and digestive issues.

Other symptoms can also occur in both types. These are weight loss, fever, night sweats, fatigue and hoarseness. Cancer can also cause high platelet and calcium counts and low sodium levels.

Doctor Jacques Fontaine and Doctor Virginia Wolf
Find a Top Mesothelioma Doctor
Gain access to top mesothelioma doctors and get help scheduling appointments.

Anti-Cancer Treatment Versus Palliative Care

You may decide you don’t want standard cancer treatment for mesothelioma. In that case, you can still consider palliative care.

This type of care manages mesothelioma symptoms. It aims to keep patients comfortable as a top priority. Some patients live longer by managing symptoms and improving general health. These options are available even when a patient turns down traditional cancer treatments.

Most palliative options use standard therapies for cancer. They are often much less aggressive. Palliative therapies focus on tumors that are causing the worst symptoms. These include surgery, chemotherapy and radiation therapy.

Other options include pleurodesis, thoracentesis, pain medication and physical therapy. These therapies do not target tumors. They can improve general health and may boost the immune system.

It’s vital to start palliative care therapies as soon as possible. They can help maintain quality of life and let some patients live longer.

Managing Pain with Palliative Care

Some people are reluctant to take pain medicine because they have fears about potential side effects and becoming addicted. Palliative care specialists have extensive experience helping people manage pain with medication and know side effects can be controlled.

Addiction is rare and shouldn’t be a concern for most people with mesothelioma. It’s more important to keep pain to a minimum, so patients can enjoy a higher quality of life.

Opiate-based pain medicine, such as morphine and tramadol, are effective at controlling cancer-related pain. Certain antidepressants help to reduce pain, while steroids can reduce pain caused by inflammation.

Over-the-counter pain medicine, including NSAIDs such as ibuprofen, is helpful for mild to moderate pain. Be careful taking NSAIDs on your own because they can easily damage the stomach’s lining and cause ulcers if taken for too long or in combination with alcohol.

Other palliative care treatments enable patients to live fuller lives. Complementary therapies, such as occupational therapy, help patients engage in activities, while physical therapy helps people feel better in their bodies.

Ask your doctor for a referral to a palliative care specialist if one isn’t available at your treatment center.

mesothelioma guide
Free Mesothelioma Guide
Receive mesothelioma guide overnight. Learn about your Stage 3 mesothelioma diagnosis, top doctors and how to pay for treatment.

Studies on Survival Without Treatment

Most studies focus on how treatments can improve mesothelioma survival rate, so there is little research regarding survival in untreated patients.

However, a few studies have reported on survival without treatment:

  • The 2019 study published in Thoracic Surgery that reported about a third of mesothelioma patients receive no treatment also reported their survival rate. Of the 3,419 mesothelioma patients included in the study, 31.1% decided against receiving treatment, and their overall survival was 10.2 months.
  • An MD Anderson study did report on life expectancy for untreated cases in 2011. The study reviewed survival in 238 cases of mesothelioma diagnosed between 1977 and 2009. The average survival for untreated patients was 6.4 months. Treated patients lived an average of 11.3 months.

Tumor Grading and Life Expectancy

In 2011, a study published in Modern Pathology reported on a prognostic factor known as nuclear grading, or tumor grading, in pleural mesothelioma patients with epithelioid tumors. This study did not report on untreated patients, but it did report on a prognostic factor that can be used to estimate how fast a tumor may grow and how well it will respond to aggressive treatment.

Tumor grading is measured by several factors such as cell abnormalities and how rapidly the mesothelioma cells are dividing. These factors are associated with survival and response to treatment, which can help doctors identify the best patients for aggressive treatment.

Patients with a low tumor grade tend to respond better to treatment and live longer, which makes them great candidates for anti-cancer treatment. Patients with a high tumor grade are unlikely to respond well to treatment, which means they may benefit less. You can talk to your doctor about whether your pathology report included tumor grading to weigh the risks and benefits for your personal case.

Tumor Grades and Survival

  • Grade 1 average survival is 28 months
  • Grade 2 average survival is 14 months
  • Grade 3 average survival is 5 months

Making Decisions About Treatment

If you’re on the fence about treatment, you may consider waiting three months until your next imaging scan, which allows your doctor to assess how quickly the mesothelioma is growing.

Knowing how fast it is growing will help your doctor provide a mesothelioma prognosis that is specific to your individual case. It will also help them decide whether trying chemotherapy makes sense after waiting to observe the growth rate.

During the three-month waiting period, patients can consider seeing an oncology dietitian or an integrative oncologist to access complementary therapies that may boost the immune system.

Making decisions about mesothelioma treatment may feel scary or bewildering. It can feel hard to understand the risks and benefits of treatment while facing fears about having cancer.

Consider writing down the questions and concerns you have about electing treatment or foregoing treatment. You may have to ask yourself some difficult questions such as, “Am I OK with having a shorter life expectancy if I don’t receive treatment?”

Talk to Your Doctor

It is important to be honest with your doctor about how you feel. Even though it may seem hard to express your concerns, it is best to tell your doctor what you are worried about.

Your doctor can address your specific fears and concerns, and explain the strategies they can use to limit or avoid certain side effects. If you express that quality of life is your primary concern, your doctor can closely monitor your response to treatment and make changes along the way to ensure you don’t experience unwanted side effects.

Some people who refuse mesothelioma treatment may experience backlash from family and doctors. Certain family members may not understand the situation and may have difficulty accepting a patient’s choice to refuse treatment.

Some doctors may push aggressive treatment because they have a goal to provide patients with more time, while others encourage patients to join clinical trials. Despite pressures you may feel from family or physicians, ultimately, you make the decision about the treatments you want or don’t want.

Survivor Sallie M. Lived for Years Without Anti-Cancer Treatment

When Sallie Morton was diagnosed with pleural mesothelioma at the age of 87 in June 2013, her doctors advised against aggressive treatment.

They said the cancer was too progressed for surgery and that Morton was too advanced in age to withstand the health effects of chemotherapy. They connected her with hospice right away, and she put her affairs in order.

Morton took the news relatively well. She felt grateful for the good life she had lived, and peacefully accepted the prognosis. She had a talc pleurodesis to stop fluid from building around her lungs, and it offered great relief of her breathing difficulties.

Doctors expected Morton’s health to quickly decline within months, but she shocked everyone as she continued to feel well. Morton loved the hospice team, but after 22 months of hospice care it became clear she was stable. Morton left hospice and continued living in an active retirement community in southern California.

Morton had a scan of her lungs done when she left hospice, just to see how things were looking. Only a few tumors were found around her lung. It seemed she had a very slow-growing type of mesothelioma.

Without any anti-cancer treatment, she lived for four years with mesothelioma.

Beating the Odds: Sallie Morton
Sallie Morton is among the 8.3% of women in her age range who survived more than four years after a diagnosis.
Pleural Mesothelioma survivor, Sallie Morton
Sallie Morton, 91, doesn’t let her pleural mesothelioma diagnosis define her.

Mesothelioma didn’t stop Morton from enjoying her life. She managed the symptoms and took time to travel along the California coastline, staying beachside, appreciating the state’s landscape and pleasant weather.

“Thank you No. 1 for the talc pleurodesis, and No. 2 for not pushing treatment on me. I got to travel as a result,” Morton said in 2015.

Cases like Morton’s are atypical when it comes to mesothelioma, but some people can live comfortably for years with mesothelioma without anti-cancer treatment. Palliative therapies like pain management, physical therapy and the talc pleurodesis that Morton had, keep mesothelioma patients comfortable as they live with the disease.

While it may feel scary to face the unknown after turning down mesothelioma treatment, palliative care and hospice care can maintain quality of life. A good support system also helps people to live well with mesothelioma.

lawyers standing together
Get the Compensation You Deserve
people watching webinar on computer
Watch Our Free Mesothelioma Webinars
scientists in laboratory
Immunotherapy & Mesothelioma Clinical Trials