How Does Radiation Therapy Treat Mesothelioma?
The main goal of radiation therapy is to improve life expectancy by preventing cancer cells from spreading. Doctors use it either in combination with other treatments or alone as a palliative therapy to manage symptoms.
Oncologists have used radiation as a cancer treatment for decades, and technological advances have made it a highly refined treatment. Well-targeted radiation can kill cancer cells without causing the serious side effects that often accompany chemotherapy.
A 2016 study from researchers at New York’s Icahn School of Medicine reviewed the outcomes for thousands of pleural mesothelioma patients. Overall survival at the two- and five-year marks were nearly double for patients who received radiation therapy, regardless of what other treatments were used.
Doctors can give radiation therapy to patients in different stages of mesothelioma for a variety of reasons.
Benefits of Radiation Therapy for Mesothelioma
- Improved Survival: When combined with surgery and chemotherapy, radiation can help you live longer by reducing the risk of local recurrence. Some patients live three to five years longer with this approach.
- Pain Relief: Radiation therapy alleviates pain by reducing the size of mesothelioma tumors. This relieves pressure on the lungs and chest. Approximately 60 percent of mesothelioma patients report symptom relief after radiation therapy.
- Seeding Prevention: During surgery, microscopic cancer cells can move to new areas. This is known as seeding. Radiation therapy along incision sites is common. Even modest radiation at surgery or drain tube sites can help.
Types of Radiation for Mesothelioma
Radiation for malignant mesothelioma can be applied externally and internally. The internal form is called brachytherapy. The external form is called external beam radiation therapy (EBRT).
EBRT is more commonly used for pleural mesothelioma because it has proven more effective.
External Beam Radiation Therapy
External beam radiation is noninvasive and involves high-energy rays directly targeting malignant tumors. It’s performed by experienced radiologists who consider the tumor size, location, staging of the cancer and general health of the patient.
To help reduce the risk of adverse reactions, a computer guides the radiation machine to deliver specific doses to precise areas, making sure healthy cells are not damaged.
The radiation beam conforms to the 3-D shape of the tumor and is emitted in multiple doses. This permits higher radiation doses within the tumor, while minimizing the dose to the surrounding organs and tissues.
The most common and effective type of EBRT for mesothelioma is intensity-modulated radiation therapy. IMRT is an advanced form of three-dimensional conformal radiation therapy. It changes the strength of beams in certain areas, allowing it to precisely target tumors.
External beam radiation is fast and painless, and each session takes only a few minutes. Setup time — getting you in the right position for treatment — can take longer. Treatments are usually given five days a week for several weeks.
Brachytherapy is a type of radiation therapy that kills cancer cells with a radioactive material implanted in the tumor.
Doctors may place the radioactive material during surgery or using a hollow tube with the aid of an imaging scan. Brachytherapy may also be applied temporarily to biopsy and surgical scars to prevent cancer from spreading.
It has been effective in treating lung cancer when placed into a tumor site, but it is seldom used for the treatment of mesothelioma.
Free Mesothelioma Treatment Guide
Information, books, wristbands and more for mesothelioma patients and caregivers.Get Your Free Guide
Timing Impacts Results
Doctors apply external beam radiation therapy at different times for different effects. EBRT as a single treatment can be applied at any time to control pain.
When combined with surgery for pleural mesothelioma, EBRT can be applied after, before or during the procedure.
Radiation Therapy After Surgery
Traditionally, multimodal therapy for pleural mesothelioma begins with chemotherapy followed by surgery and then radiation therapy once the patient recovers from surgery.
In this setting, radiation is used to kill cancer cells left behind in surgery. This technique delays or reduces the risk of local recurrence.
About half of early-stage patients with epithelioid mesothelioma can live longer than five years with this treatment.
Surgery for Mesothelioma After Radiation Therapy (SMART)
This approach to treatment is a reversal of the traditional protocol. It has produced impressive results for some mesothelioma patients.
In a 2015 study, specialists at two leading cancer centers in Toronto estimated a median overall survival of 51 months for pleural mesothelioma patients using the SMART approach. Around 66 percent of patients with early-stage epithelioid tumors lived longer than three years.
It takes an experienced multidisciplinary team to safely execute the SMART approach. A high level of radiation is applied to the lung, which could be fatal if the lung isn’t subsequently removed. This means that once a patient receives radiation, they must follow through with surgery.
Intraoperative Radiation Therapy
Intraoperative radiation therapy (IORT) is used as part of a surgical procedure.
A radiologist applies the beams to the affected areas to help prevent any seeding or spreading of the cancer cells during the operation. A concentrated dose of radiation is delivered to the tumor site immediately after the tumor is removed.
This option may help some patients finish treatment sooner, reducing the need for additional radiation therapy following surgery. Patients who require additional radiation sessions can get a boost from IORT and typically experience fewer complications.
Radiation Therapy Process
Most people are not sure what to expect when receiving radiation therapy. In general, patients go through an initial consultation, get imaging scans, and then receive treatment on an outpatient basis.
- First Appointment: During the consultation visit, you will meet with a radiation oncologist to discuss the best approach for your case. You might be asked to sign a consent form once you are fully informed of the process and want to proceed with treatment.
- Imaging Scans: To ensure accurate and safe application, imaging scans are performed to determine the exact size, shape and location of tumors. The application of radiation is based on these images to ensure safety.
- Treatment: A medical professional will explain what you need to do before, during and after treatment. They will help position you and apply protective coverings to prevent radiation exposure to healthy tissue. Radiation is typically applied one or more times a week for several weeks.
- Follow-Up Appointment: During follow-up appointments, your doctor will check you for signs of side effects. Imaging scans will be taken to keep a close watch on how radiation affected the size of your tumors.
Common Side Effects of Radiation Therapy
Radiation therapy is not painful during administration. There’s no need to worry about pain while receiving the treatment.
After treatment, some people may experience skin irritation around the area where radiation was delivered.
Side effects of radiation are most often temporary and are typically more constrained than those of chemotherapy, which can affect the entire body. However, some radiation side effects may be chronic and appear months or years after the patient finishes treatment.
Most side effects develop as tissue damage accumulates over several sessions of radiation. A single cycle may last up to eight weeks. As treatment progresses, side effects often become more severe.
Common side effects of radiation:
- Skin Problems: Radiation-related irritation, known as radiodermatitis, is most common at the point where the radiation beam was focused. It can cause rashes, redness and a tight feeling or swelling. Peeling or darkening of the skin may occur.
- Fatigue: Loss of energy is typically most severe two to four hours after a radiation session. It may also peak between the third and fifth week of treatment as the healing process uses more of the patient’s energy.
Have a Question About Radiation Therapy?
Our Patient Advocates can answer questions about different treatment options for mesothelioma patients.
Radiation Side Effects by Mesothelioma Type
Advanced methods of delivering radiation therapy can help reduce the amount of healthy tissue exposed to radiation. However, some side effects may still occur in the area where the radiation entered the body.
The type of mesothelioma diagnosis affects how a person’s body will react to radiation therapy.
Receiving radiation treatments to the chest could temporarily intensify symptoms of pleural mesothelioma such as shortness of breath, difficulty swallowing and coughing.
In rare cases, scarring of the lungs, called fibrosis, may occur.
Radiation to the chest can also cause inflammation of the lungs or the lining of the heart. There is also a risk of damage to the heart muscle, resulting in cardiac toxicity.
Other rare complications include fluid buildup (pleural effusions), collapsed lungs and calcification of the lymph nodes. Research shows that pleural effusions, if they develop at all, are typically reported within six months of the initial radiation treatment.
Dr. Emanuela Taioli Epidemiologist at Mount Sinai Hospital in New York City
“If you’re not a candidate for surgery, radiotherapy can do almost as well as surgery. And the combination of the two is even better, like 40 percent better, and that’s significant.”
Radiation therapy has limited usefulness for those with peritoneal mesothelioma. The reason is location.
Peritoneal cancer involves the lining of the abdominal cavity. Radiation can be extremely toxic to the small intestines, liver, kidneys and other organs in this area.
The only kind of radiation used on peritoneal patients is to prevent cancer spreading to biopsy and surgical scars.
Nausea and vomiting are the most common side effects in patients who receive radiation to the abdomen. These side effects can be caused by radiation damage to the gastrointestinal tract. These side effects are also common in patients receiving other mesothelioma treatments, especially chemotherapy.
Inflammation in the bladder, known as cystitis, may also occur. It may be difficult to completely empty your bladder, urinate at normal intervals or control the flow of urine from your bladder when you cough or sneeze.
In rare cases, urine may appear bloody or the bladder may begin to cramp or spasm. These side effects may appear within three to five weeks of treatment.
Is Radiation Therapy Right for You?
Despite recent advances, a number of experts question the merits of radiation therapy for mesothelioma. These concerns arise from the inconsistent results published in clinical trials and scientific studies.
The decision to include radiation therapy in your treatment plan is up to you and your oncologist. The potential benefits of the therapy might outweigh the risks and side effects.
However, you need to discuss the pros and cons with your oncologist to make an informed decision.
Share this article
Last Modified February 27, 2019
12 Cited Article Sources
Ohri, N. et al. (2016, October 1). Definitive Radiation Therapy Is Associated With Improved Survival in Non-Metastatic Malignant Pleural Mesothelioma. 30649-6/fulltext
Retrieved from: http://www.redjournal.org/article/S0360-3016(16)
De Perrot, M. et al. (2015, October 16). Accelerated hemithoracic radiation followed by extrapleural pneumonectomy for malignant pleural mesothelioma. 01986-8/abstract
Retrieved from: http://www.jtcvsonline.org/article/S0022-5223(15)
Zauderer, M. & Krug, L.M. (2012, June 1). The Evolution of Multimodality Therapy for Malignant Pleural Mesothelioma.
Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3321839/
Akmansu, M. et al. (2012, August 9). Radiotherapy applications of patients with malignant mesothelioma: A single center experience.
Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3863306/
Nakano, T. (2008, March). Current therapies for malignant pleural mesothelioma.
Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2698270/
Moore, A., Parker, R. & Wiggins, J. (2008, December 19). Malignant mesothelioma.
Retrieved from: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2652430/
Iyer, R. & Jhingran, A. (2006, October 31). Radiation injury: imaging findings in the chest, abdomen and pelvis after therapeutic radiation.
Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1805064/
American Brachytherapy Society. (n.d.). Brachytherapy Frequently Asked Questions.
Retrieved from: http://www.americanbrachytherapy.org/aboutBrachytherapy/BrachyFAQFinal2.pdf
Stevens, C.W., Forster, K.M. & Smythe W.R. (2006). Radiotherapy for Mesothelioma. In K. O'Byrne & V. Rusch (Eds.), Malignant Pleural Mesothelioma (pp. 315-333). New York: Oxford University Press.
Giuseppe, S., et al. (2008). Non-Surgical Treatment of Malignant Pleural Mesothelioma: Radiotherapy and Chemotherapy. In A. Baldi (Ed.), Mesothelioma from Bench Side to Clinic (pp. 405-412). New York: Nova Science Publishers, Inc.
Chahinian, A. (2002). Treatment of Malignant Mesothelioma: Radiotherapy and Chemotherapy. In B. Robinson & A. Chahinian (Eds.), Mesothelioma (pp. 185-199). London: Martin Dunitz.
- Smith, R. & Hahn, S. (2005). Treatment of Mesothelioma with Radiotherapy. In Pass, H., Vogelzang, N. & Carbone, M. (Eds.), Malignant Mesothelioma (pp. 616-627). New York: Springer.