Mesothelioma

What Is Mesothelioma?

Mesothelioma is a rare cancer caused by asbestos exposure. It affects the tissue lining the lungs, abdomen or heart. Mesothelioma is a rare and aggressive cancer.

Doctors classify mesothelioma based on where it forms on the mesothelium throughout the body. Symptoms, treatment and prognosis depend on where the cancer develops.

Tumor location determines the 4 types of mesothelioma

Pleural Mesothelioma

The most common type of mesothelioma is pleural. It forms in the pleura, the protective lining around the outside of the lungs.

Peritoneal Mesothelioma

The second-most common type is peritoneal, which forms in the abdominal lining. It has a much higher survival rate, and surgery is typically more successful than with pleural mesothelioma.

Pericardial Mesothelioma

The pericardial type affects about 1% of patients. Treatment options are much more limited. The median survival is 2 to 6 months.

Testicular Mesothelioma

The rarest type is testicular mesothelioma. Treatment options are much more limited, but about one-third of patients live for at least 10 years.

As this rare cancer progresses, mesothelial tumors can spread or metastasize to the lining of other organs and lymph nodes. In later stages of this malignant cancer, tumors can also spread to organs, such as the liver, lungs, kidneys, adrenal glands or spleen.

What Are the Symptoms of Mesothelioma?

Common mesothelioma symptoms are dry cough, shortness of breath, chest pain, abdominal pain and unexplained weight loss. The location of cancer determines which symptoms develop and how severe they can become. 

Respiratory symptoms of pleural mesothelioma primarily affect the lungs and chest cavity. These can include a painful and dry cough, wheezing and chest pain. Symptoms of peritoneal mesothelioma develop in and around your abdomen and include abdominal swelling, nausea, distension and pain.

Pericardial mesothelioma may cause unique symptoms such as heart palpitations and murmurs. Symptoms of testicular mesothelioma include testicular swelling and pain.

Mesothelioma misdiagnosis is frequent because its symptoms can resemble other cancers and illnesses. Fatigue, weight loss and fever commonly occur in other cancers. Talk to your doctor if you’ve been exposed to asbestos in the past and are experiencing these symptoms. Early diagnosis of any disease often leads to a better prognosis and longer life expectancy.

What Causes Mesothelioma?

Asbestos exposure is the main cause of mesothelioma. Repeated exposure to asbestos-contaminated products, such as talc and older construction materials, increases the risk of developing mesothelioma. An average of 20 to 60 years passes between the first asbestos exposure and the development of symptoms, which is called the mesothelioma latency period.

As Dr. Marcelo DaSilva, chief of thoracic surgery and medical director at AdventHealth Cancer Institute, tells The Mesothelioma Center, “Patients inhale or ingest asbestos, which causes chronic inflammation in the mesothelium. This can lead to genetic changes where cell DNA changes into a mesothelioma cancer cell.”

Occupational asbestos exposure is the No. 1 cause of mesothelioma. Construction workers, industrial workers, firefighters, military veterans and those in similar occupations may have been exposed to asbestos. The military heavily used asbestos as did factories and construction projects. Historically, asbestos was used because of its low cost, resiliency and resistance to heat and electricity. Asbestos is still present in many older building materials, machinery and consumer products.

If you or a loved one was exposed to asbestos, screenings for signs of disease with X-rays and other tests can help catch mesothelioma cancer early. Tell your doctor about your exposure and ask how frequently you should be screened.

How to Diagnose & Stage Mesothelioma

Doctors diagnose mesothelioma by using tests that examine the inside of the chest and abdomen. A biopsy is necessary to confirm a mesothelioma diagnosis. If mesothelioma cancer is suspected, doctors will recommend taking a tissue sample, also known as a biopsy. Doctors use this tissue sample to look for the presence of specific malignant mesothelioma cells.

Doctors use several other tests to diagnose mesothelioma. Blood tests may be used, but they cannot detect mesothelioma alone. Most people initially undergo a chest X-ray. If abnormal growth or fluid around your lung is detected, doctors recommend imaging scans, such as CT, MRI or PET.

After a mesothelioma diagnosis, your doctor will review your pathology report to determine the cancer’s cell type. The three primary types of mesothelioma cells respond differently to treatment, and prognosis varies for each cell type.

Staging Mesothelioma Cancer

Determining the cancer stage is important because it helps doctors create your treatment plans and predict patient prognoses. The 4 stages of mesothelioma range from stage 1 (early-stage) to stage 4 (late-stage).

The Four Stages of Malignant Mesothelioma

The stages of mesothelioma advance as tumors grow and spread. These stages are based on tumor size and location. Each type of mesothelioma grows and spreads uniquely depending on where the tumors originated.

Median life expectancy for pleural mesothelioma ranges from 14.9 months to 22.2 months, depending on the stage. Treatments your doctor recommends are primarily based on the cancer’s stage, cell type and your overall health.

What Are Your Mesothelioma Treatment Options?

Mesothelioma treatment may include surgery, chemotherapy, radiation and immunotherapy. Doctors develop individualized treatment plans based on cancer location, cell type and stage.

If you’re diagnosed in the early stages of mesothelioma you’ll benefit most from multimodal therapy using surgery, chemotherapy and radiation. Surgical and palliative treatment options vary by cancer location. The sarcomatoid cell type limits treatment options, while the epithelial cell type responds best to all forms of treatment.

“Supportive care medicine is a new specialized branch of medicine that reduces pain, increases appetite and boosts morale,” said Dr. Jacques Fontaine, director of the Mesothelioma Research and Treatment Center at Moffitt Cancer Center. “Every mesothelioma patient should ask to be seen by this type of medical specialist, in addition to a thoracic surgeon and medical oncologist.”

You may be eligible for mesothelioma clinical trials that test newer therapies. Though not every mesothelioma treatment is suitable for each patient, most patients benefit from palliative care to help manage symptoms of mesothelioma.

Survivor Story

Survivor Story

Daniel McCarthy Mesothelioma Survivor

Mesothelioma survivor still soaring the skies

Diagnosed in 2017, pleural mesothelioma survivor Daniel McCarthy stays remarkably active at 82. After surviving aggressive surgery performed by specialist Dr. Abraham Lebenthal at the Boston VA Hospital, McCarthy underwent chemotherapy and radiation, which slowed him but didn’t stop his push to stay engaged. Today, he walks daily, reads considerably and writes about his adventures.

Read Daniel’s Story

Finding Mesothelioma Treatment

Finding a mesothelioma specialist at a top mesothelioma treatment center is the best way for you to benefit from the latest therapies and improve a mesothelioma prognosis. Mesothelioma specialists understand more about the disease and its treatment than general oncologists. 

Top mesothelioma doctors have years of experience developing personalized treatment plans for patients. They can access the latest treatments and medical technology at renowned cancer centers and work on multidisciplinary teams to provide a comprehensive mesothelioma treatment plan.

Our Patient Advocates help people get appointments with these experts throughout the U.S. “Patients are surprised that we can schedule and register them with a specialist for a second opinion,” said Danielle DiPietro, a Patient Advocate with The Mesothelioma Center.

Peritoneal mesothelioma survivor, Kasie Coleman shared, “Not many doctors have knowledge treating mesothelioma. Everyone should get a second opinion. If not for a second opinion, I wouldn’t have survived.”

What Is the Mesothelioma Life Expectancy?

Life expectancy for mesothelioma patients is about 12 months with treatment. According to statistics on mesothelioma, about 12% of people with pleural mesothelioma and 65% with peritoneal mesothelioma live for 5 years or longer.

While you can’t change your age or cancer stage, you can decide to get treatment and adopt a healthy lifestyle. Mesothelioma patients who make these types of positive changes may also experience remission, a period of having no signs or symptoms of cancer.

What Should I Do After My Mesothelioma Diagnosis?

The impact of a rare cancer diagnosis such as mesothelioma can feel like too much to handle. Worrying and feeling confused about how you can move forward is expected.

Focus on getting excellent treatment and know there are steps you and your loved ones can take to empower your family with knowledge, resources and hope.

Commonly Asked Questions About Mesothelioma

Is mesothelioma a type of lung cancer?

Mesothelioma is not a form of lung cancer. While both are types of cancer, mesothelioma grows on the pleura, which is the lining that covers the lungs, diaphragm and chest cavity. Lung cancer develops within the lung space.

Is mesothelioma curable?

Mesothelioma is not curable. However, researchers continue investigating new therapy options in clinical trials. Some patients live several years beyond the average life expectancy. Recent treatment advancements, such as immunotherapy, provide patients hope for an eventual cure.

Is mesothelioma always fatal?

While mesothelioma is fatal in most people, many outlive their initial life expectancy. A small number of people have survived for more than a decade after diagnosis. Detecting mesothelioma and receiving treatment from a mesothelioma specialist are the best ways to extend life expectancy.

How can I help a loved one with mesothelioma?

Friends and family members can provide vital support to loved ones diagnosed with mesothelioma. They can help with everyday tasks, such as doing housework, providing transportation to appointments or preparing meals. They might help schedule appointments, pay bills and explore legal options. Loved ones also provide crucial emotional support.

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