Dr. Samantha Ruff

About Dr. Samantha Ruff

Dr. Samantha Ruff is a surgical oncologist at UVA Health who specializes in peritoneal mesothelioma and gastrointestinal cancers. She’s also an assistant professor of surgery at UVA. 

Her research background at the National Institutes of Health gives her a strong foundation in understanding how mesothelioma behaves at the molecular level. Dr. Ruff’s research aims to identify potential better treatments through targeted therapies for people diagnosed with peritoneal mesothelioma. 

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Medical Education & Experience

• Emily Couric Clinical Cancer Center, UVA Health
• The Ohio State University (Fellowship)
• National Institutes of Health Clinical Center (Fellowship)
• Northwell Health (Residency)
• Donald & Barbara Zucker School of Medicine at Hofstra/Northwell (M.D.)
• Johns Hopkins University (B.S.)

Associations, Awards & Recognition

• American Board of Surgery, Complex General Surgical Oncology
• American Board of Surgery, General Surgery
• Clinical Excellence Award, National Institutes of Health
• Multiple Awards for Clinical and Professional Excellence, Northwell Health Residency

Why Choose Dr. Samantha Ruff for Peritoneal Mesothelioma

Dr. Ruff is one of the few surgeons who performs cytoreduction surgery combined with HIPEC for people with peritoneal mesothelioma. This procedure delivers a heated chemotherapy wash directly into the abdomen immediately after visible tumors are removed to kill any cancer that remains. Dr. Ruff’s specialized peritoneal mesothelioma surgery expertise benefits her patients at UVA Health.

Her patients consistently rate Dr. Ruff highly for her clear explanations, empathy and willingness to answer questions. She includes patients in treatment decisions and takes time to discuss all available options. For people diagnosed with peritoneal mesothelioma in Virginia and the surrounding region, Dr. Ruff offers advanced surgical and compassionate care at a leading academic cancer center.

Publications of Dr. Samantha Ruff

• Ruff, S. et al. (2026, March). ASO Author Reflections: Hormonal Status May Impact Outcomes in Peritoneal Mesothelioma After CRS/HIPEC. Retrieved from https://www.researchgate.net/publication/403149139_ASO_Author_Reflections_Hormonal_Status_May_Impact_Outcomes_in_Peritoneal_Mesothelioma_After_CRSHIPEC
• Ruff, S. et al. (2026, February). ASO Visual Abstract: Patterns and Predictors of Sentinel Lymph Node Biopsy Utilization in High- and Low-Risk Thin Melanomas. Retrieved from https://www.researchgate.net/publication/401187769_ASO_Visual_Abstract_Patterns_and_Predictors_of_Sentinel_Lymph_Node_Biopsy_Utilization_in_High-_and_Low-Risk_Thin_Melanomas
• Ruff, S. et al. (2025, July). Patient-Reported Outcomes During Neoadjuvant Therapy for Gastrointestinal Cancer and Their Association with Postoperative Complications. Retrieved from https://www.researchgate.net/publication/393323777_Patient-Reported_Outcomes_During_Neoadjuvant_Therapy_for_Gastrointestinal_Cancer_and_Their_Association_with_Postoperative_Complications
• Ruff, S. et al. (2025, April). Outcomes for Medicaid Patients with Colorectal Cancer Are Improved in Affluent Neighborhoods, but Disparities Persist. Retrieved from https://www.researchgate.net/publication/391026223_Outcomes_for_Medicaid_Patients_with_Colorectal_Cancer_Are_Improved_in_Affluent_Neighborhoods_but_Disparities_Persist?_tp=eyJjb250ZXh0Ijp7InBhZ2UiOiJzY2llbnRpZmljQ29udHJpYnV0aW9ucyIsInByZXZpb3VzUGFnZSI6bnVsbH19