WT1 Protein

WT1 is a protein commonly found in mesothelioma cells. Mesothelioma specialists look for WT1 during the diagnostic process. Researchers are working on immunotherapy techniques that target WT1.

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This page features: 11 cited research articles

Proteins are important building blocks of cells. Special proteins called transcription factors regulate DNA expression by turning genes on and off. The WT1 protein plays a role in the development of the kidneys, reproductive organs and other parts of the body.

The WT1 protein is created by the WT1 gene. This gene is abnormally expressed in many types of cancer, leading to high levels of the protein in cancer cells.

WT1 is useful for cancer diagnosis, and it may be useful for developing new cancer treatments.

WT1 Fast Facts

  • Protein used in immunohistochemistry
  • Expressed in almost all epithelioid mesothelioma cases
  • Less useful for identifying sarcomatoid mesothelioma
  • Cancer vaccine being tested in clinical trials

The process of diagnosing mesothelioma is complex, becase mesothelioma tumors often resemble more common types of cancer. Looking at which proteins are expressed in cells helps doctors figure out where cancer originally developed in the body.

This diagnostic technique is called immunohistochemistry. WT1 is one of the most useful markers for identifying mesothelioma.

WT1 may also play a role in making mesothelioma cells resistant to chemotherapy, according to a 2017 study in Pathology & Oncology Research. When researchers deactivated WT1 in laboratory mesothelioma cells, their chemoresistance was suppressed.

WT1 may provide the basis for effective immunotherapy treatments for mesothelioma.

Researchers have experimented with a cancer vaccine and a gene therapy that use WT1 as a target.

WT1 as an Immunohistochemical Marker for Mesothelioma

The International Mesothelioma Interest Group (IMIG) identifies WT1 as one of the most useful markers for mesothelioma diagnosis. According to their 2012 guidelines, mesothelioma tumors test positive for WT1 in 70 to 95 percent of cases.

Lung carcinomas and adenocarcinomas rarely express WT1, which makes this marker useful for confirming a pleural mesothelioma diagnosis. It is also useful for diagnosing peritoneal mesothelioma in men.

A 2014 study in Clinical & Translational Oncology suggests WT1 is associated with a better prognosis. The researchers reviewed 52 pleural mesothelioma cases and found patients with WT1-positive tumors tended to have longer survival times.

The WT1 protein is not useful for diagnosing peritoneal mesothelioma in women. This is because gynecologic cancers can also test positive for it. In addition, mesothelioma of the sarcomatoid cell type often does not express WT1.

Because of these limitations, doctors must check other mesothelioma markers such as calretininand D2-40. They also check markers that should test negative in mesothelioma, to rule out more common forms of cancer.

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Last Modified September 17, 2018

Registered Nurse and Patient Advocate

Karen Selby joined Asbestos.com in 2009. She is a registered nurse with a background in oncology and thoracic surgery and was the director of a tissue bank before becoming a Patient Advocate at The Mesothelioma Center. Karen has assisted surgeons with thoracic surgeries such as lung resections, lung transplants, pneumonectomies, pleurectomies and wedge resections. She is also a member of the Academy of Oncology Nurse & Patient Navigators.

Matt Mauney, Content Writer at Asbestos.com
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5 Cited Article Sources

  1. U.S. National Library of Medicine. (2018, April 17). WT1 gene.
    Retrieved from: https://ghr.nlm.nih.gov/gene/WT1
  2. Cancer Genetics Web. (2017, March 9). WT1.
    Retrieved from: http://www.cancerindex.org/geneweb/WT1.htm
  3. Plones, T. et al. (2017, January). Turning back the Wheel: Inducing Mesenchymal to Epithelial Transition via Wilms Tumor 1 Knockdown in Human Mesothelioma Cell Lines to Influence Proliferation, Invasiveness, and Chemotaxis.
    Retrieved from: https://link.springer.com/article/10.1007%2Fs12253-016-0181-3
  4. Cedres, S. et al. (2014, September). Expression of Wilms' tumor gene (WT1) is associated with survival in malignant pleural mesothelioma.
    Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/24323466
  5. Husain, A. et al. (2013, May). Guidelines for pathologic diagnosis of malignant mesothelioma: 2012 update of the consensus statement from the International Mesothelioma Interest Group. Retrieved from: https://www.ncbi.nlm.nih.gov/pubmed/22929121
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