Based on Your Reading:
Get a Mesothelioma Treatment Guide
Find a Top Mesothelioma Doctor
Access Help Paying for Treatment
Bevacizumab
Table Of Contents
As one of the world’s best-selling cancer drugs, bevacizumab is quickly becoming a promising option for mesothelioma patients. Also known as the brand name Avastin, bevacizumab inhibits the formation of new blood vessels in tumors, effectively slowing the growth of cancer cells.
Written by Karen Selby, RN • Edited By Walter Pacheco • Medically Reviewed By Dr. Jeffrey Velotta
Fact Checked
Our fact-checking process begins with a thorough review of all sources to ensure they are high quality. Then we cross-check the facts with original medical or scientific reports published by those sources, or we validate the facts with reputable news organizations, medical and scientific experts and other health experts. Each page includes all sources for full transparency.
Reviewed
Asbestos.com is the nation’s most trusted mesothelioma resource
The Mesothelioma Center at Asbestos.com has provided patients and their loved ones the most updated and reliable information on mesothelioma and asbestos exposure since 2006.
Our team of Patient Advocates includes a medical doctor, a registered nurse, health services administrators, veterans, VA-accredited Claims Agents, an oncology patient navigator and hospice care expert. Their combined expertise means we help any mesothelioma patient or loved one through every step of their cancer journey.
More than 30 contributors, including mesothelioma doctors, survivors, health care professionals and other experts, have peer-reviewed our website and written unique research-driven articles to ensure you get the highest-quality medical and health information.
About The Mesothelioma Center at Asbestos.com
- Assisting mesothelioma patients and their loved ones since 2006.
- Helps more than 50% of mesothelioma patients diagnosed annually in the U.S.
- A+ rating from the Better Business Bureau.
- 5-star reviewed mesothelioma and support organization.
Testimonials
My family has only the highest compliment for the assistance and support that we received from The Mesothelioma Center. This is a staff of compassionate and knowledgeable individuals who respect what your family is experiencing and who go the extra mile to make an unfortunate diagnosis less stressful. Information and assistance were provided by The Mesothelioma Center at no cost to our family.LashawnMesothelioma patient’s daughter
How to Cite Asbestos.com’s Article
APA
Selby, K. (2024, February 2). Bevacizumab. Asbestos.com. Retrieved April 17, 2024, from https://www.asbestos.com/treatment/drugs/bevacizumab/
MLA
Selby, Karen. "Bevacizumab." Asbestos.com, 2 Feb 2024, https://www.asbestos.com/treatment/drugs/bevacizumab/.
Chicago
Selby, Karen. "Bevacizumab." Asbestos.com. Last modified February 2, 2024. https://www.asbestos.com/treatment/drugs/bevacizumab/.
What Is Bevacizumab?
Bevacizumab is cancer fighting drug that is sometimes classified as a chemotherapy drug. It is an antiangiogenic agent, meaning that it stops blood vessel formation. This stops the supply of oxygen and nutrients to tumors to slow their growth and spread.
Doctors may inject it or give it through an intravenous drip, a process that can take a few hours. Patients generally need the drug once every three weeks. In 2021, researchers studied how well bevacizumab worked with atezolizumab for mesothelioma patients. After one year, 61% of these patients had no further signs of disease and 85% were still alive.
Researchers tested a drug called bevacizumab (Avastin) on some people with mesothelioma. They combined it with cisplatin and pemetrexed (Alimta). In a study done in France in 2016, the people taking all three drugs lived an average of 18.8 months. This compared to 16.1 months for those who only took chemotherapy alone.
In early clinical trials, bevacizumab (Avastin) helped some mesothelioma patients live longer when combined with chemotherapy drugs cisplatin and pemetrexed (Alimta). In a 2016 phase III clinical trial in France, patients taking a combination of the three drugs survived an average of 18.8 months, compared to 16.1 months for patients only receiving cisplatin and pemetrexed.
Bevacizumab has rare but serious side effects. The phase III clinical trial showed that most of these were not too difficult to deal with.
How Does Bevacizumab Work?
Bevacizumab works differently than chemotherapy. It stops tumors from getting oxygen and nutrients. It inhibits angiogenesis, which is the growth of blood vessels within the tumor.
When angiogenesis happens, it helps the mesothelioma cells in the body to grow and spread. But if there is no angiogenesis, the cancer cells don’t get enough of what they need to survive and eventually die off.
Bevacizumab can stop mesothelioma from spreading and kills cancer cells that are already present.
Bevacizumab Information
| Name | Avastin |
| Alternate Names | Bevacizumab |
| Manufacturer | Roche/Genetech |
| Dosage | 15 mg/kg every three weeks |
| Administration Route | Intravenous |
| Active Ingredient | Bevacizumab |
| Drug Class | Anti-angiogenic agent |
| Medical Code | J9035, C9257 |
| Related Drug | Bevacizumab-awwb (Mvasi) |
| Interacting Drug | Quadramet, deferiphrone, pantiumumab, sunitinib, thalidomide |
| Medical Studies | Cisplatin, Pemetrexed and Bevacizumab for Untreated Malignant Mesothelioma |
| FDA Warning | Gastrointestinal perforation or fistula, arterial thromboembolic events, hypertension, proteinuria, ovarian failure, infusion reactions, posterior reversible encephalopathy syndrome |
It is used in combination with other chemotherapy drugs such as a cisplatin-based chemotherapy regimen. Some clinicians have also combined bevacizumab with a second-line chemotherapeutic agent called gemcitabine.
Bevacizumab works to stop angiogenesis while other drugs have a direct toxic effect on cancer cells. Doctors worry that taking this medicine in combination with others may cause more side effects than usual.
Side Effects of Bevacizumab
Bevacizumab may cause dizziness, dry mouth, fatigue, heartburn and loss of appetite. In rare cases, it may cause severe side effects such as blood clots in the lungs, hemorrhaging, holes in the stomach and low white blood cell count. These potentially deadly complications are most common when it is used in conjunction with a chemotherapy drug.
A study of clinical trial results revealed that patients treated with bevacizumab and chemotherapy are 1.5 times more likely to die because of treatment complications than patients treated with chemotherapy alone.
Results of Bevacizumab Studies
A 2008 study tested the effects of bevacizumab with chemotherapy in 24 mesothelioma patients. They previously underwent other treatments with no positive results.
The combination was successful in slowing disease progression in half of patients. Overall, patients lived a median of 5.8 months after being treated with the drug. Researchers reported that it was well-tolerated and warranted further study.
In a case study the following year, a mesothelioma patient underwent treatment with bevacizumab and gemcitabine after other treatments had failed to shrink his tumor or control his symptoms. The combination helped prevent fluid buildup and pain, leading to a better quality of life.
This finding suggests that bevacizumab may aid in palliative, symptom-reducing care in addition to potentially curative, life-extending treatment.
Get Free Recipes for Mesothelioma Patients
Mesothelioma Trust Funds
Find Active Mesothelioma Clinical Trials
