The chemotherapeutic drug gemcitabine is most often used to treat pancreatic, ovarian and breast cancers. Doctors also found success in the treatment of pleural and peritoneal mesothelioma and certain types of lung cancer, and often use the drug in combination with another chemotherapy drug to treat these forms of cancer.
Used or tested in: Pancreatic cancer, breast cancer, ovarian cancer, lung cancer and mesothelioma cancer.
Most chemotherapeutic drugs work by killing cells with complex chemical reactions. Gemcitabine can slow the growth of pleural mesothelioma by killing cancer cells and interfering with DNA replication.
These drugs target cells that are dividing rapidly, including cancer cells. Unfortunately, the treatment may also affect some healthy cells, including cells that are involved in hair growth and immunity. This is why many chemotherapy patients lose hair and become easily susceptible to illness.
Gemcitabine was discovered and developed by scientists at the pharmaceutical company Eli Lilly. Gemzar is the registered name of gemcitabine for injection. Mesothelioma patients who do not respond well to platinum-based chemotherapy drugs like cisplatin or carboplatin may do well on gemcitabine instead.
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Gemcitabine chemotherapy is most often performed on an outpatient basis and is administered intravenously. Treatment typically involves a trip to a doctor's office, clinic or hospital. The procedure usually takes a few hours, with the actual administration of the drug lasting around 30 minutes. In most cases, it is administered once a week for up to seven weeks, though the length of treatment and strength of dosage will depend on the type and stage of cancer.
The drug may be administered alone or in combination with another chemotherapy drug. It may be used in first-line or second-line chemotherapy regimens for mesothelioma. First-line chemotherapy with gemcitabine is most often given in combination with another chemotherapy drug, such as cisplatin. Second-line chemotherapy with this drug may be administered alone or in combination, depending on the patient and how they responded to first-line chemotherapy.
When considering treatment with gemcitabine, it is necessary for patients to inform their doctor of current medications being taken, including all prescription drugs and any vitamins, supplements or over-the-counter medications. In addition, anyone who has impaired liver or kidney function is generally not advised to use gemcitabine, as the drug can cause severe liver and kidney damage. Since gemcitabine and most chemotherapy drugs are known to be harmful to unborn babies, women who are pregnant or breastfeeding should not use this drug.
Numbness or weakness, most often on one side of the body
Confusion, balance impairment, or impaired vision or speech
Fever, chills, aching body (similar to symptoms of flu)
Sores or white patches inside the mouth
Pain or swelling at the location where gemcitabine was administered
Those who are treated with chemotherapy drugs have reduced immune system function since the drug kills certain immune cells. If you are taking gemcitabine for mesothelioma, it's important to avoid contact with people who have colds or other infections. A medical face mask may be worn to protect you from contact with germs.
Several Phase II clinical trials have investigated gemcitabine's effectiveness on mesothelioma. Some Phase II trials report higher response rates or higher overall survival rates than other trials report. Despite inconsistency in results, the general consensus is that the drug can benefit people with mesothelioma.
In 2002, an Australian Phase II clinical trial evaluated the combination of gemcitabine and cisplatin as first-line chemotherapy for pleural mesothelioma. Researchers reported a partial response (meaning the tumor shrank to some degree) in 33 percent of participants. The tumor was stabilized (meaning no tumor growth) in 60 percent of participants. Only 8 percent of participants had progressive tumor development while on the treatment. Participants reported improved quality of life following recovery from treatment and improved respiratory function.
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In 2012, results were published from a Phase II clinical trial led by mesothelioma expert Dr. Hedy Kindler on the combination of gemcitabine, cisplatin and the anti-angiogenesis drug bevacizumab. Anti-angiogenesis drugs block the formation of new blood vessels, which is the pathway through which tumors spread cancerous cells in the body. The addition of bevacizumab improved progression-free survival and overall survival in participants with lower pretreatment VEGF levels, but was not significant enough among all participants to warrant further study. However, evidence suggests that combining bevacizumab with pemetrexed could be more effective; a French Phase II/III clinical trial is evaluating the combination and the preliminary results are promising in terms of extending survival rate.
In 2013, a preclinical study performed in mice found benefit in the combination of gemcitabine, vitamin C and EGCG (epigallocatechin-3-gallate, a green tea polyphenol). The combination effectively reduced tumor growth and invasiveness in mice with peritoneal mesothelioma. The addition of vitamin C and EGCG to a lower dose of gemcitabine produced a survival increase that was identical to survival with a higher dose of gemcitabine. These results indicate that the addition of nutritional compounds may increase the effectiveness of gemcitabine at lower doses, which could diminish side effects.
Studies continue to investigate the best ways to administer gemcitabine for the treatment of mesothelioma. The drug's effectiveness may be improved with the addition of other chemotherapy drugs, targeted therapies and nutrition, and trials are ongoing to improve the outcomes of people treated with the drug. People facing mesothelioma who undergo treatment with this drug may experience a reduction of symptoms, improved quality of life and extended survival.
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