Small Cell Mesothelioma
Small cell mesothelioma is an extremely rare subtype that can be mistaken for small cell lung cancer. As the name suggests, cancer cells in these tumors are smaller than cells in other forms of mesothelioma.
- Written by Karen Selby, RN
- Edited By Walter Pacheco
- Medically Reviewed By Dr. Rupesh Kotecha
Asbestos.com is the nation’s most trusted mesothelioma resource
The Mesothelioma Center at Asbestos.com has provided patients and their loved ones the most updated and reliable information on mesothelioma and asbestos exposure since 2006.
Our team of Patient Advocates includes a medical doctor, a registered nurse, health services administrators, veterans, VA-accredited Claims Agents, an oncology patient navigator and hospice care expert. Their combined expertise means we help any mesothelioma patient or loved one through every step of their cancer journey.
More than 30 contributors, including mesothelioma doctors, survivors, health care professionals and other experts, have peer-reviewed our website and written unique research-driven articles to ensure you get the highest-quality medical and health information.
About The Mesothelioma Center at Asbestos.com
- Assisting mesothelioma patients and their loved ones since 2006.
- Helps more than 50% of mesothelioma patients diagnosed annually in the U.S.
- A+ rating from the Better Business Bureau.
- 5-star reviewed mesothelioma and support organization.
Testimonials
"My family has only the highest compliment for the assistance and support that we received from The Mesothelioma Center. This is a staff of compassionate and knowledgeable individuals who respect what your family is experiencing and who go the extra mile to make an unfortunate diagnosis less stressful. Information and assistance were provided by The Mesothelioma Center at no cost to our family."LashawnMesothelioma patient’s daughter
How to Cite Asbestos.com’s Article
APA
Selby, K. (2022, September 29). Small Cell Mesothelioma. Asbestos.com. Retrieved October 6, 2022, from https://www.asbestos.com/mesothelioma/small-cell/
MLA
Selby, Karen. "Small Cell Mesothelioma." Asbestos.com, 29 Sep 2022, https://www.asbestos.com/mesothelioma/small-cell/.
Chicago
Selby, Karen. "Small Cell Mesothelioma." Asbestos.com. Last modified September 29, 2022. https://www.asbestos.com/mesothelioma/small-cell/.
Table Of Contents
What Is Small Cell Mesothelioma?
The cells that define this cell type have a uniform round appearance featuring a nucleus that takes up the majority of the cell. This type of mesothelioma grows in a pattern similar to small cell carcinoma, though mesothelioma tumors do not display the stream, ribbon or rosette patterns that appear in the subtype of lung carcinoma.
These tumors most commonly grow in the peritoneum (abdominal lining), but they can also arise in the pleura (lung lining) or the pericardium (heart sac).
This variant is most commonly classified as a subtype of the epithelial cell type, but many mesothelioma tumors with small cell features are biphasic, indicating a combination of both epithelial and sarcomatoid cells.
Most of these tumors are not made up entirely of small cells. Instead, they often also contain normal mesothelioma cells and other assorted neoplastic cells. Roughly half or more of all cells in a tumor should display a small cell pattern for the tumor to qualify as this type.
Small Cell Mesothelioma Facts
- Extremely rare variant of mesothelioma
- May be misdiagnosed as other types of cancer
- Differentiated using immunohistochemistry
- Doctors use standard mesothelioma treatment approaches
Diagnosis and Treatment of Small Cell Mesothelioma
It can be challenging to correctly diagnose this cell type. The cells look very similar to other small cell neoplasms, so doctors must run immunohistochemical tests to differentiate between the diseases.
Small cell mesothelioma often resembles:
- Small cell lung carcinoma (SCLC)
- Desmoplastic small round cell tumor (DSRCT)
- Peripheral neuroectodermal tumor (PNET)
- Lymphoma
A single biopsy specimen may not always contain a representative sample of the cells in the entire tumor. In one study, for example, small cells made up 80 to 100 percent of the biopsy material, but only 15 to 20 percent of the full tumor. Doctors may need to retrieve several samples to make an accurate mesothelioma diagnosis.
Once the samples undergo immunohistochemical staining, the cells in the tumor will test positive for different compounds, helping the medical team narrow down the diagnosis. Although small cell mesothelioma and small cell carcinoma have similar-looking cells, each disease reacts to different chemical markers. Identifying the correct type of cancer is vital, because different cancers respond to different types of treatment.
There have been too few reported cases of small cell mesothelioma to develop a detailed standard of treatment, so doctors rely on standard mesothelioma treatment approaches.
Although small cell lung cancer is considered more aggressive than other types of lung cancer, it is unclear whether small cell mesothelioma is associated with a significantly different prognosis than other types of epithelial mesothelioma.
In a 2012 study of eight small cell mesothelioma patients, six patients passed away during the observation period. The mean survival time of these patients was 8.2 months.
In 2020, researchers characterized small cell mesothelioma as having similar cell morphology to SCLC, but a different immunohistochemical profile. They concluded that the rare variant has a poor prognosis with a mean survival of about 8 months.
