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Thoracentesis, also knowns as a pleurocentesis, is mainly used to diagnose the cause of pleural fluid buildup around the lungs. Because thoracentesis is minimally invasive, doctors sometimes perform it as a palliative treatment for certain pleural mesothelioma patients as well.

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When mesothelioma causes fluid to build up between the two layers of the pleural lining around the lungs, it can lead to chest pain, discomfort and breathing difficulties.

This condition is called a pleural effusion. It is healthy to have a small amount of fluid in the pleura, but when excess fluid buildup puts pressure on one or both lungs, removing the fluid through a hollow needle through a thoracentesis procedure, also known as a pleurocentesis, is the simplest way to give the patient relief.

Thoracentesis Facts

  • Involves removing pleural fluid buildup through a hollow needle.
  • Used to treat and help diagnose cause of pleural effusions.
  • Less permanent solution than pleurodesis procedure or catheter insertion.
  • Less invasive palliative treatment option for late-stage mesothelioma patients.

Thoracentesis is also referred to as “pleural fluid aspiration,” “pleural tap,” “pleurocentesis” and “thoracocentesis.”

A chest X-ray can reveal a pleural effusion but usually not the reason for it. Because many different diseases can cause pleural effusions, doctors examine the fluid collected through thoracentesis to try to identify the root cause. However, thoracentesis testing is not reliable enough to confirm a mesothelioma diagnosis, which usually depends on analyzing a cancer tissue sample collected through a biopsy.

Palliative Thoracentesis Versus Other Treatments

Palliative therapies for pleural mesothelioma aim to relieve painful symptoms and improve a patient’s quality of life, rather than attempting to cure the cancer. Removing excess pleural fluid alleviates chest pain and shortness of breath by reducing pressure on the chest and lungs and providing more space for the lungs to expand during respiration.

Thoracentesis has become less common as a mesothelioma treatment compared to other procedures:

  • Many mesothelioma patients benefit more from pleurodesis, which drains excess fluid and then seals the pleural space to prevent fluid from building up there again.

  • Another option is for doctors to insert a catheter that continuously drains the pleura, so the patient does not have to undergo repeated thoracentesis procedures.

  • Mesothelioma patients who have early-stage cancer and are in otherwise good health may be eligible for a more aggressive surgery that removes the diseased part of the pleura altogether.

However, for patients too weak to withstand one of these options, or who wish to avoid a hospital stay, the less invasive thoracentesis procedure remains a tried-and-true technique for alleviating the symptoms caused by a pleural effusion.

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The Thoracentesis (Pleurocentesis) Procedure

The patient may assume a seated position throughout the procedure or lie down if necessary. The doctor sterilizes the skin around the insertion point and provides local anesthesia to numb the area.

Next, the doctor inserts a long, hollow needle called a cannula between the ribs, guided by ultrasound or CT scan images. The patient may experience a feeling of pressure, but the anesthesia usually blocks any pain. Once the needle is inserted, the doctor drains the pleural effusion until some or all of the fluid is removed, depending on the goal of the thoracentesis. The entire process takes about 15 minutes.

The doctor usually sends the extracted fluid to a lab for analysis. After removing the needle and dressing the wound, the doctor often orders a chest X-ray as well to confirm enough fluid was removed and to ensure there is no sign of a collapsed lung.

Risks and Complications

While complications are rare, they can occur. The most common serious complication of the procedure is a collapsed lung, also known as pneumothorax. This can happen if the doctor accidentally punctures the lung or disrupts an accumulation of air in the pleural cavity.

Other possible complications include:

  • Bleeding
  • Pain
  • Infection
  • Diaphragm injury
  • Laceration to spleen or liver
  • Tumor seeding (invasion of cancer cells along the needle track)

Complications are more common among certain groups of patients. Patients with a history of lung surgery face greater risks, as do patients with a chronic, irreversible lung disease such as asthma or emphysema. Patients with any condition that affects normal blood clotting may also face a higher risk of complications.

One 2010 study identified patients who would benefit most from thoracentesis while experiencing the lowest risk of complications. Out of 446 patients involved in the study, including a number of malignant mesothelioma patients, the incidence of pneumothorax was significantly lower in patients whose procedure was guided by an ultrasound.

Another factor that increased the risk of complications in participants was the presence of symptoms of their primary disease. Thoracentesis led to complications for only one asymptomatic patient (out of 328 total), yet 15 of 118 symptomatic patients developed complications.

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Registered Nurse and Patient Advocate

Karen Selby joined in 2009. She is a registered nurse with a background in oncology and thoracic surgery and was the regional director of a tissue bank before becoming a Patient Advocate at The Mesothelioma Center. Karen has assisted surgeons with thoracic surgeries such as lung resections, lung transplants, pneumonectomies, pleurectomies and wedge resections. She is also a member of the Academy of Oncology Nurse & Patient Navigators.

Walter Pacheco, Managing Editor at
Edited by
Dr. Daniel Landau, mesothelioma specialist & medical content reviewer for
Medical Review By

12 Cited Article Sources

The sources on all content featured in The Mesothelioma Center at include medical and scientific studies, peer-reviewed studies and other research documents from reputable organizations.

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  6. Fox Chase Cancer Center. (2013, December 23). Pleural Disease. Retrieved from:
  7. Light, R. (2008, January 13). Pleural Effusion. New England Journal of Medicine. Retrieved from:
  8. Mohammed, I., Maddirala, S. and Khan, A. (2010, October). Evaluating Clinical Predictors of Complications of Thoracentesis. CHEST Journal. Retrieved from:
  9. Karkhanis, V., and Joshi, J. (2012). Pleural effusion: diagnosis, treatment, and management. Retrieved from:
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  11. Van Zandwijk, N. et al. (2013, December). Guidelines for the diagnosis and treatment of malignant pleural mesothelioma. Retrieved from:
  12. National Heart, Lung, and Blood Institute. (2016, December 9). Thoracentesis. Retrieved from:

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Last Modified August 27, 2020

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