Get to Know Dr. John Wrangle
Medical oncologist Dr. John Wrangle is an innovator whose research laboratory at the Medical University of South Carolina is playing a major role in advancing the use of novel immunotherapy combinations with groundbreaking clinical trials.
Work in the Wrangle Research Laboratory led to the immunotherapy combination of pembrolizumab and N-803 being used as part of an ongoing, 700-site clinical trial orchestrated by the National Cancer Institute for the treatment of non-small cell lung cancer.
Wrangle plays a key role in the Lung and Thoracic Cancer Program at the Medical University of South Carolina, the state’s only NCI-designated cancer center. It is recognized for its high treatment standards involving a multidisciplinary collaboration of specialists.
Treatment options may include a combination of surgery and chemotherapeutic and targeted agents based on individual molecular characteristics.
Specialties of Dr. John Wrangle
- Lung cancer
- Esophageal cancer
- Pleura mesothelioma
- Targeted therapy
Dr. John Wrangle’s Experience and Education
- Medical University of South Carolina Hollings Cancer Center
- Johns Hopkins Hospital (Fellowship)
- Emory University School of Medicine (Residency)
- Tulane University School of Medicine (M.D.)
Awards and Certifications
- Board certified in internal medicine
- Board certified in medical oncology
- Smart State Burtschy Family Distinguished Endowed Chair in Lung Cancer Research
Publications of Dr. John Wrangle
- Alexander, M. & Wrangle, J. (2020, November 1). Can We MIRror the Efficacy of Immune Checkpoints With miRNAs? Journal of Thoracic Oncology.
- Yoshida, A. et al. (2019, September 18). SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors. Science Advances.
- Wrangle, J.M. et al. (2018, May). ALT-803, an IL-15 superagonist, in combination with nivolumab in patients with metastatic non-small cell lung cancer: a non-randomized, open-label, phase 1b trial. Lancet Oncology.
- Wrangle, J.M. et al. (2018, February 1). IL-2 and Beyond in Cancer Immunotherapy. Journal of Interferon & Cytokine Research.
- Dimou, A., Sherman, C. & Wrangle, J. (2016, July). Imaging in Advanced Non-Small Cell Lung Cancer: A Medical Oncology Perspective. Journal of Thoracic Imaging.