Richard Alexander

Richard Alexander M.D.

Surgical Oncologist, Associate Chairman for Clinical Research

Specialty: Surgical Oncology
Medical Treatment Center: University of Maryland Greenebaum Cancer Center 22 South Greene Street, S4B05A, Baltimore, MD 21201

About Dr. Alexander

H. Richard Alexander, M.D., is a world-renowned surgical oncologist and cancer researcher. He has a special interest in abdominal cancers, including peritoneal mesothelioma.

In addition to treating patients at the University of Maryland Marlene and Stewart Greenebaum Cancer Center, Alexander serves as a professor and associate chair for clinical research in the Department of Surgery at the University of Maryland Medical Center.

In his clinical practice, Alexander offers innovative treatment options for various difficult-to-treat cancers. He developed an interest in peritoneal mesothelioma early in his career and has since made numerous breakthroughs about the nature of the disease and, more importantly, how doctors can treat it most effectively.

Research and Treatment Approach

Alexander made one of his most noteworthy research discoveries by analyzing mesothelioma tumors at the molecular level. Using advanced techniques, his research team identified proteins within the cancerous cells that are crucial for the tumor’s survival.

By employing novel methods to eliminate the cancer-sustaining proteins, Alexander essentially found a way to prevent mesothelioma tumors from growing. He has confirmed this approach’s success in cell cultures and laboratory mice, and will soon start the next phase of research that aims to improve the results of peritoneal mesothelioma patients in clinical trials.

Fast fact: Baltimore Magazine named Dr. Alexander one of 2010’s Top Docs for general surgical oncology.

Another major focus of Alexander’s work is peritoneal dissemination, or the spread of tumors within the abdominal cavity. To find ways to better manage this challenging clinical situation for patients with peritoneal mesothelioma and other abdominal cancers, Alexander has researched a variety of treatment combinations.

His three-mode treatment approach for mesothelioma combines traditional intravenous chemotherapy, an additional high-dose chemotherapy treatment delivered directly to the abdominal cavity and cytoreductive surgery, which aims to systematically remove abdominal tumors. Alexander was surprised to find that some mesothelioma patients treated with this approach fared well long after receiving therapy.

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Navy and NCI Experience

Alexander began his career in the military, spending eight years on active duty with the U.S. Navy. He earned his medical degree from Georgetown University School of Medicine and completed his residency in general surgery at the Walter Reed National Military Medical Center, formerly known as the National Naval Medical Center. At the conclusion of his military service, Alexander entered a fellowship in surgical oncology at the Memorial Sloan-Kettering Cancer Center in New York.

Prior to joining the University of Maryland’s cancer center, Alexander spent nearly 17 years with the National Cancer Institute (NCI). He ultimately became deputy director for the institute’s Center for Cancer Research, where he presided over a program to develop innovative surgical procedures for patients with challenging cancers. He also served the NCI as chief of the surgical metabolism section and chairman of the gastrointestinal malignancies section.

Alexander continues to research improved treatment options for patients with peritoneal mesothelioma and several gastrointestinal cancers. He has authored more than 250 journal articles on these topics and has been invited to host lectures across the United States and abroad.

Interview with Dr. Alexander

H. Richard Alexander, M.D., doesn’t spend much time looking at the past to see what will work best for a patient with peritoneal mesothelioma. He looks to the future to see what will work better.

Alexander, a surgical oncologist and clinical researcher at the University of Maryland’s Greenebaum Cancer Center, has earned a reputation as an innovator, avoiding the one-size-fits-all approach.

“The best approach to successfully treat mesothelioma is highly individualized, based on a patient’s circumstances,” he said. “No one formula or approach is necessarily best for all.”

After 16 years at the National Institutes of Health (NIH), Alexander came to Greenebaum in his search of cutting-edge treatment options — and to feed his passion for finding answers.

MPM (malignant peritoneal mesothelioma) is a fascinating disease. In many ways, it has a very predictable biological behavior. But in many other ways, it behaves unpredictably.

At the NIH’s National Cancer Institute, Alexander became the leader in developing isolated hepatic perfusion treatment, a technique to circulate high doses of chemotherapy directly into the liver of patients with inoperable cancer. With a “closed loop” method, it protects other organs in the body and allows patients to avoid the most serious side effects that would come with such high doses of the drugs.

There is no better testament to his work than his patients.

“He’s always thinking outside the box,” said Larry Davis, a recent mesothelioma surgery patient from South Florida, who was diagnosed five years ago. “We think alike.”

“He doesn’t go by the book, like a lot of them,” Davis continued. “He’s the only one I’d trust. He’s not there to disappoint anyone, and neither am I. He’s a big reason why I’ve lasted as long as I have. This is his life, not his hobby.”

Researcher and Surgeon

Alexander thrives on finding novel treatments for patients with very difficult cancer diagnoses. It’s why he relishes his role as both a researcher and a surgeon.

His clinical practice focuses on advanced cancers of the liver and peritoneal cavity, which includes mesothelioma. His research is related to developing new therapies for advanced solid organ cancers.

Before coming to the University of Maryland, he held the title of deputy director at the National Cancer Institute’s Center for Cancer Research. At Greenebaum, he is both a top surgeon and the associate chairman for clinical research.

Much of the work he does now, like assessing the molecular profiles of the tumors that stem from mesothelioma, he started at the National Institutes of Health. It’s how he is able to tailor treatment to each individual.

His advice to someone who has recently been diagnosed is pretty simple.

Take the initiative to find out where to go for experienced and expert advice. I am still amazed at the number of people who do not get referred to a specialty center.

Additional Resources

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Tim Povtak is an award-winning writer with more than 30 years of reporting national and international news. His specialty is interviewing top mesothelioma specialists and researchers, reporting the latest news at mesothelioma cancer centers and talking with survivors and caregivers.

  1. University of Maryland Medical Center. (n.d.). H. Richard Alexander, Jr., MD. Retrieved from
  2. University of Maryland Marlene and Stuart Greenebaum Cancer Center. (n.d.). Researcher Information: H. Richard Alexander, M.D. Retrieved from
  3. University of Maryland Medical Center. (2013, August 2). Malignant Peritoneal Mesothelioma. Retrieved from
  4. UMMC Videos. (2011, September 23). UMMC Physician Profile: H. Richard Alexander, Jr., M.D. YouTube. Retrieved from
  5. Mesothelioma Applied Research Foundation. (n.d.). The Meso Foundation Science Advisory Board: H. Richard Alexander, MD, Chair. Retrieved from

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