Last modified: June 14, 2021
Certifications:Board Certified in Pulmonary Disease
About Dr. Moon
Dr. Edmund Moon specializes in diseases that affect the respiratory system, such as malignant pleural mesothelioma. His current research is helping to identify and develop new types of immunotherapy for mesothelioma.
Moon is an associate professor of medicine at the Hospital of the University of Pennsylvania. He earned a Bachelor of Arts in biology and psychology from The Johns Hopkins University in 2000. In 2004, Moon graduated from the Doctor of Medicine program at the University of Maryland School of Medicine.
At Penn Medicine, Moon investigates the anti-tumor function of T cells, a type of immune cell the body typically uses to fight infection. His research focuses on discovering how the immune system interacts with cancer to create new and better forms of immunotherapy.
In 2019, Moon and his fellow researchers published a report titled Phase I Study of Lentiviral-Transduced Chimeric Antigen Receptor-Modified T Cells Recognizing Mesothelin in Advanced Solid Cancers.The study involved testing CAR T cells against specific biomarkers to find better ways of identifying and treating mesothelioma.
“Earlier this year, my colleagues and I published research on why some lung cancer patients may not respond to T cell immunotherapy,” Moon said, describing his recent clinical trials on immune checkpoint inhibitors. “In many cases, tumor cells can defend themselves by compensating with other inhibitory molecules.
“Our research discovered that combining therapies that blocked PD1 and TIM3 checkpoints resulted in greater tumor control than inhibiting PD1 alone,” he said. “These results will help lead to more discoveries of the optimal combination of immunotherapies for mesothelioma patients.”