Dr. Evan W. Alley

Get to Know Dr. Evan Alley

Dr. Evan Alley joined the Cleveland Clinic Florida in 2019 as section head of thoracic oncology, focusing on lung cancer, mesothelioma and other cancers of the chest. He previously served for more than a decade in Philadelphia as chief of hematology/oncology for Penn Presbyterian Medical Center and as co-director of the highly regarded Penn Mesothelioma and Pleural Program.

Alley has played a major role nationally in the study and development of pembrolizumab (Keytruda), an immunotherapy drug being used successfully by lung cancer and mesothelioma patients. Alley was the lead investigator in a clinical trial that explored the effectiveness of Keytruda with pleural mesothelioma patients.

He also did earlier investigational research work with photodynamic therapy as a mesothelioma treatment that is being used today at several different centers.

Alley graduated from the University of Kansas School of Medicine before doing his residency at Thomas Jefferson University Hospitals and his fellowship at the University of Pennsylvania.

He is a member of the International Mesothelioma Interest Group, International Association for the Study of Lung Cancer, American Society of Clinical Oncology, American Society of Hematology and American Association for Cancer Research.

In 2021, Alley published research on the effect of immunotherapy on overall survival in limited-stage small-cell lung carcinoma.

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Specialties of Dr. Evan Alley

• Pleural and peritoneal mesothelioma
• Lung cancer
• Immunotherapy
• Research

Dr. Evan Alley’s Experience and Medical Education

• University of Kansas School of Medicine (M.D.)
• Thomas Jefferson University Hospitals (Residency)
• University of Pennsylvania (Fellowship)

Awards and Certifications

• Regional Top Doctor, Castle Connolly (2018-2019)
• Double board certified in hematology and medical oncology

Mesothelioma Clinical Trials Under Evan Alley, M.D.

• Study of Pembrolizumab (MK-3475) in Participants with Advanced Solid Tumors (MK-3475-028/KEYNOTE-28).

Publications of Dr. Evan Alley

• Bange, E. et al. (2019). Impact of KRAS and TP53 Co-Mutations on Outcomes After First-Line Systemic Therapy Among Patients with STK11-Mutated Advanced Non-Small Cell Lung Cancer. JCO Precision Oncology.
• Berger, I. et al. (2019, March). Lymphangitic Carcinomatosis: A common radiographic manifestation of local failure following extended pleurectomy/decortication in patients with malignant pleural mesothelioma. Lung Cancer.
• Aggarwal, C. et al. (2019, February). Clinical Implications of Plasma-Based Genotyping With the Delivery of Personalized Therapy in Metastatic Non-Small Cell Lung Cancer. JAMA Oncology.