The Shukla Research Lab (SRL) at the University of Vermont’s Larner College of Medicine has one goal: To understand how asbestos causes disease and develop diagnostic and therapeutic approaches for asbestos-related diseases.
Part of the research at SRL involves studying early detection of mesothelioma through biomarkers, which are unique compounds that help doctors identify diseases.
SRL also researches how asbestos fibers cause mesothelioma and how inflammation plays a role in mesothelioma development.
SRL is part of the department of pathology and laboratory medicine at Larner College of Medicine. In addition to promoting research and educating future pathologists, the pathology department also offers clinical services such as diagnosing biopsy samples.
Research conducted at SRL may lead to earlier diagnoses of mesothelioma and better treatment. They’re even working on ways to prevent mesothelioma before it even has a chance to develop.
Leadership and Funding
The lab is led by Arti Shukla, Ph.D., who also serves as an associate professor in the pathology department of the University of Vermont’s Larner College of Medicine.
Shukla earned her degrees in biochemistry from Banares Hindu University in India and held a post-doctoral research position at the University of Michigan. She was a visiting scientist at the University of Vermont before becoming a research assistant professor in the university’s pathology department.
Shukla has earned numerous awards and honors including awards from the Vermont Cancer Center and invitations to peer-review mesothelioma research.
Since 2002, Shukla has published dozens of studies on asbestos and mesothelioma cancer in peer-reviewed medical journals.
Part of SRL’s research is funded by the U.S. Department of Defense, the National Institute of Environmental Health Sciences and the National Institutes of Health.
SRL is among the few research centers investigating how asbestos causes mesothelioma. Other research centers, such as the Vaccine and Immunotherapy Center and the Pacific Meso Center, focus their research on improving therapies to treat mesothelioma.
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Research on Mesothelioma
SRL’s mesothelioma research involves understanding how asbestos causes the cancer, biomarkers for early diagnosis and targeted therapies for treatment.
SRL’s team has focused on:
- Cell signaling pathways
Cell signaling pathways are the chain reactions triggered by asbestos fibers that lead to mesothelioma.
Understanding these pathways might help researchers develop drugs to prevent mesothelioma from ever developing in the first place.
Inflammasomes are a collection of proteins that detect foreign invaders — such as asbestos fibers — and activate inflammatory parts of the immune system to attack the invaders.
Asbestos appears to overactivate inflammasomes, leading to uncontrolled inflammation that contributes to the development of mesothelioma. Understanding inflammasomes may help researchers learn how to control inflammation that contributes to mesothelioma growth.
Exosomes are fluid-filled sacs released from cells that are involved in cell-to-cell communication. These sacs are made up of proteins, fats and nucleic acids (the building blocks of DNA and RNA).
Understanding exosomes may lead to the identification of a biomarker to diagnose mesothelioma in its earliest stages.
In 2018, SRL’s study on exosomes was published in The FASEB Journal. The study was the first to show asbestos exposure alters exosomes in ways that causes genetic damage in mesothelial cells.
SRL’s research is filling knowledge gaps in our understanding of exactly how asbestos fibers cause mesothelioma and how we can better diagnose and treat asbestos-related diseases.
6 Cited Article Sources
The sources on all content featured in The Mesothelioma Center at Asbestos.com include medical and scientific studies, peer-reviewed studies and other research documents from reputable organizations.
University of Vermont. (n.d.). Shukla Research Lab.
Retrieved from: https://www.med.uvm.edu/pathology/shukla-lab_new
University of Vermont. (n.d.). Shukla Research Highlights How Asbestos Causes Lung Disease Mesothelioma.
Retrieved from: https://www.med.uvm.edu/pathology/news/2018/03/27/shukla_research_highlights_how_asbestos_causes_lung_disease_mesothelioma
Willms, E. et al. (2016). Cells release subpopulations of exosomes with distinct molecular and biological properties.
Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4773763/
Edgar, J.R. (2016). Q&A: What are exosomes, exactly?
Retrieved from: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4906597/
Nature. (n.d.). Inflammasome.
Retrieved from: https://www.nature.com/subjects/inflammasome
- Munson, P. et al. (2018). Exosomes from asbestos-exposed cells modulate gene expression in mesothelial cells. Retrieved from: https://www.fasebj.org/doi/10.1096/fj.201701291RR
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Last Modified February 4, 2020