Mesothelioma Pleurodesis

The surgical procedure known as pleurodesis is used to treat pleural effusion, the buildup of fluid in the chest cavity between the lungs and their lining, called the pleural space.

Technically, the process of pleurodesis is used to eliminate the pleural space so fluid cannot continue to collect. Doctors perform this procedure by draining the fluid and inserting a talc-like substance that causes inflammation and serves to seal the pleural space.

There are two methods doctors may use to produce this inflammation. Usually, inflammation achieved chemically, but cancer doctors also use a surgical procedure to irritate the tissue. When surgery is performed, it is common for some of the suspicious tissue to be removed as well.

In the chemical pleurodesis process, the chest is first drained using a tube. Doctors then introduce a chemical into the pleural space. There are a number of chemicals that may be used, but the most common are bleomycin, tetracycline, povidone iodine, and talc. These chemicals remain in the chest for a few hours until the tissue is thoroughly irritated. Doctors then connect a tube to a suction device, which causes the two layers of the pleura to come together and seals the space where fluid once collected. This process takes place during the course of a few days because it takes some time for the fluid to drain thoroughly. During this time, anesthesia and pain medications are administered, but most patients still describe this procedure as quite painful.

The second form of pleurodesis is surgical. This surgery is performed by using either a thoracotomy or thoracoscopy. In both cases, the pleura are irritated with a rough pad, causing inflammation. As in chemical pleurodesis, the layers are then brought together so they can fuse and future fluid retention can be eliminated.

After recovering from the surgery, patients should experience a marked difference in their ability to breathe, and pain and coughing should lessen as well.

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