Mesothelioma Survivor Finds New Hope with Keytruda

Stories from Survivors

Written by Matt Mauney

Reading Time: 5 mins
Publication Date: 08/16/2018
Fact Checked
Our fact-checking process begins with a thorough review of all sources to ensure they are high quality. Then we cross-check the facts with original medical or scientific reports published by those sources, or we validate the facts with reputable news organizations, medical and scientific experts and other health experts. Each page includes all sources for full transparency.
Reviewed is the nation’s most trusted mesothelioma resource

The Mesothelioma Center at has provided patients and their loved ones the most updated and reliable information on mesothelioma and asbestos exposure since 2006.

Our team of Patient Advocates includes a medical doctor, a registered nurse, health services administrators, veterans, VA-accredited Claims Agents, an oncology patient navigator and hospice care expert. Their combined expertise means we help any mesothelioma patient or loved one through every step of their cancer journey.

More than 30 contributors, including mesothelioma doctors, survivors, health care professionals and other experts, have peer-reviewed our website and written unique research-driven articles to ensure you get the highest-quality medical and health information.

About The Mesothelioma Center at

  • Assisting mesothelioma patients and their loved ones since 2006.
  • Helps more than 50% of mesothelioma patients diagnosed annually in the U.S.
  • A+ rating from the Better Business Bureau.
  • 5-star reviewed mesothelioma and support organization.
Learn More About Us


My family has only the highest compliment for the assistance and support that we received from The Mesothelioma Center. This is a staff of compassionate and knowledgeable individuals who respect what your family is experiencing and who go the extra mile to make an unfortunate diagnosis less stressful. Information and assistance were provided by The Mesothelioma Center at no cost to our family.
Mesothelioma patient’s daughter
  • Google Review Rating
  • BBB Review Rating

How to Cite’s Article


Mauney, M. (2022, September 23). Mesothelioma Survivor Finds New Hope with Keytruda. Retrieved June 2, 2023, from


Mauney, Matt. "Mesothelioma Survivor Finds New Hope with Keytruda.", 23 Sep 2022,


Mauney, Matt. "Mesothelioma Survivor Finds New Hope with Keytruda." Last modified September 23, 2022.

Diagnosed with pleural mesothelioma in 2016, Jim Huff went 15 months with no new tumor growth. His only treatment: A twice-daily dose of CBD oil.

When his cancer finally began to progress, spreading to his abdomen, Huff explored other options. Chemotherapy and radiation therapy were still last resorts, and he never was a candidate for surgery.

Fortunately, Huff’s oncologist — Dr. Thierry Jahan at the University of California, San Francisco (UCSF) Medical Center — was able to get Huff on the immunotherapy drug Keytruda (pembrolizumab) without enrolling him in a clinical trial.

“In [Jahan’s] study, he’s testing two different forms of chemo plus Keytruda,” Huff told “He knew I didn’t want to do any chemo, and I guess I was too late to enroll in the trial anyway, but he was able to backdoor me in with Keytruda only.”

It appears to be working.

Since starting Keytruda in late February, two CT scans have shown no new tumor growth. He continues to take CBD oil in the morning and evening and THC oil — the psychoactive concentrate — before bed to help with sleep.

“Something is working, a combination or whatever,” the 68-year-old said. “I’m just riding this wave as long as I can.”

No Apprehensions with Keytruda

Huff makes the 65-mile trip to UCSF Medical Center for Keytruda infusions every three weeks. He plans to continue as long as it keeps working.

The only real side effects Huff has experienced from the checkpoint inhibitor is fatigue and what doctors and patients refer to as the “Keytruda rash.”

“I’m a little tired on the day of the treatment and the next day,” he said. “I get a little itchiness from time to time where the rash is, which is mostly on my arms and forehead.”

The rash is constant, but Huff controls it with the CBD oil. Doctors tell him it’s a sign the Keytruda is working.

“I have no apprehensions at all with Keytruda,” he said. “[Jahan] is even more excited about my success with it than I am. He calls me his favorite patient.”

While Huff’s tumors aren’t growing, they also aren’t shrinking.

“No change is fine by me,” he said. “Yeah, I’d love to see them shrink and eventually go away, but if they’re not growing, that’s just about as good for me. It lets me live is what it does. I don’t have to worry about anything. I think I could get another 10 years out of this at least.”

scientists researching in lab
Find Immunotherapy Clinical Trials
Learn how to access mesothelioma clinical trials utilizing immunotherapy.

Keytruda Still an Experimental Treatment for Mesothelioma

Keytruda has a 21 to 25 percent long-term survival rate for patients with PD-L1-positive non-small cell lung cancer (NSCLC), according to a statistical analysis of the KEYNOTE-010 and KEYNOTE-001 clinical trials.

The FDA approved Keytruda for NSCLC and several other cancers, not mesothelioma. Most mesothelioma patients get Keytruda through clinical trials or compassionate-use programs.

Huff hasn’t had any issues getting access to Keytruda and counts himself lucky to be in the percentage of patients finding success with it.

Keytruda and similar immunotherapy drugs can cost $150,000 a year. Luckily, Huff’s infusions are covered entirely by Medicare and private insurance.

“Fortunately, I don’t have to worry about that aspect of it,” he said. “It’s a tremendous weight lifted. I don’t feel fortunate that I have mesothelioma, but I feel fortunate that I have all my circumstances.”

Still Playing Guitar and Traveling

Huff doesn’t cough much anymore but does tire easily.

“I don’t know day-to-day how much energy I’m going to have,” he said. “I may get up in the morning and feel like I could run a marathon, or I could be crawling out to the living room. I don’t even know how much energy I’m going to have when I start doing something. Sometimes I get halfway through and realize I’m overdoing it.”

He’s been taking private guitar lessons between doctor appointments but admits he doesn’t practice enough.

“If my parents found out that they were paying for these lessons and I wasn’t practicing enough, they would be very upset,” he said. “I tell my teacher that I bet he has a field day telling his wife that this guy comes in every lesson and doesn’t get any better.”

Yardwork is left to Huff’s wife these days. He tries to do some cooking and chores around the house.

Traveling is limited to day trips and weekend trips by car because Huff refuses to fly without the CBD oil he swears by.

“My wife came up with an idea to take my brother’s trailer and travel some place for a couple of weeks, fly back for the Keytruda appointment and then fly to wherever the trailer is and carry on,” he said. “That would allow me to take the CBD oil before getting on the plane and again after I get back. I think I’m more paranoid about not taking it than getting caught with it.”

And for good reason. Huff had a progression-free survival of 15 months taking only CBD oil. Now he is relying on a combination of the oil and immunotherapy to keep his mesothelioma under control.

“[Jahan] told me whatever I was doing to keep doing it,” he said. “Keytruda, for me, seems to be a wonder drug. It seems to be doing everything it’s supposed to, and I’ll just continue to ride this wave as long as it’s there.”

open book icon vector illustration
Free Mesothelioma Guide
Get Answers to All Your Mesothelioma Questions