Thoracic Malignancies
Medical Oncology

Get to Know Dr. Jeffrey Melson Clarke

Medical oncologist Dr. Jeffrey Clarke believes strongly in the personalization of treatment for his patients, including those diagnosed with lung cancer or pleural mesothelioma.

Clarke works closely with patients and families, developing treatment plans that cater to individual needs and fit into the multidisciplinary approach most often used at the Duke Cancer Center.

“With each patient interaction, my goal is to individualize the care for that patient,” Clarke said. “The most rewarding part for me is forming relationships with patients and families, develop those over time and help patients through their treatment and cancer care.”

Clarke administers both traditional chemotherapy and novel immunotherapies in guiding patients through treatment. He has been involved in numerous clinical trials that have helped change the way cancers have been treated in recent years.

He is the principal investigator in an ongoing clinical trial for lung cancer patients at Duke that involves nivolumab and ipilimumab, two immunotherapy drugs also being studied with mesothelioma.

Specialties of Dr. Jeffrey  Melson Clarke

  • Medical oncology
  • Pleural mesothelioma
  • Lung cancer
  • Immunotherapy
  • Chemotherapy
  • Clinical trials
  • Developmental therapeutics

Dr. Jeffrey Melson Clarke’s Experience and Education

  • Duke University Cancer Center
  • Assistant professor of medicine, Duke University
  • Duke University Medical Center (Residency and fellowship)
  • Indiana University School of Medicine

Awards and Certifications

  • Board certified in internal medicine and medical oncology
  • The V Foundation for Cancer Research fellowship grant

Publications of Dr. Jeffrey Melson Clarke

  • Moravan, M.J. et al. (2020, April 1). Current multidisciplinary management of brain metastases. Cancer.
  • Conroy, J. et al. (2019, January 24). Next generation sequencing of PD-L1 for predicting response to immune checkpoint inhibitors. Journal for ImmunoTherapy of Cancer.
  • Yi, J.S. et al. (2017, December 15). Immune Activation in Early-Stage Non-Small Cell Lung Cancer Patients Receiving Neoadjuvant Chemotherapy Plus ipilimumab. Clinical Cancer Research.
  • Isaacs, J., Clarke, J. & Ready, N. (2020, April). Keynote 42: Pembrolizumab, PD-L1, and where to draw the line. Annals of Translational Medicine.