6 Min Read
Last Updated: 02/02/2024
Fact Checked

Written by Karen Selby, RN | Medically Reviewed By Dr. Daniel Landau | Edited By Walter Pacheco

When to Consider a Pneumonectomy

When deciding if a pneumonectomy should be done, doctors look at where the tumors are located. How much they have spread to nearby lymph nodes is important. Lymph nodes are special parts of your body that help fight off infection and are found between both lungs.

A 10-year study of 193 pneumonectomies found the most common condition in the procedure. Squamous cell carcinoma was the most common at 69%, followed by adenocarcinoma (22%).

Surgeons must think carefully about the risks and benefits when deciding whether to do a pneumonectomy or a lobectomy. Even with better surgery techniques and post-op care, it can still be dangerous.

In one study of 433 people, those who had a pneumonectomy were almost twice as likely to die compared to those who had a lobectomy (9.4% vs 5%). It’s important for surgeons to make sure that the risks are worth it in order for patients to get more time and have a better quality of life.

Doctors will generally not recommend this surgery in cases where a patient’s cancer has already spread to other parts of the body or if the remaining lung is not in good working condition. In addition, candidates must be in relatively good health with strong heart function.

In some difficult surgeries, doctors must convert from a pleurectomy with decortication to extrapleural pneumonectomy. In a 2021 study, researchers concluded this was the case in about 10% of surgeries and resulted in a lower median overall survival of about 29 months, compared to 57 months for pleurectomy with decortication.

Surgical Consultation for Pneumonectomy

A surgical consultation is an important step toward a pneumonectomy. During this consultation, your medical records will be looked over so that everyone can get an idea of what the surgery would involve for you. You’ll also have a chance to ask questions about the procedure and learn more about it.

Before the procedure, the medical team will review your past and current records to make sure you are a good fit. During this time, it is important for you to ask questions or talk about any worries that may come up. You can do this either in person or through video chat.

The Procedure and Recovery

This surgery is performed under general anesthesia. The surgeon begins the operation by performing a thoracotomy, which is a long incision on the same side of the chest as the diseased lung.

Sometimes all or part of a rib will be removed to get a better view and help facilitate surgery. The affected lung will then be collapsed, and any attached blood vessels will be stapled across and divided or clamped, cut, and tied off, along with the bronchus — the main tube flowing air into the lung.

extrapleural pneumonectomy

The diseased organ can then be removed through the incision. The cut tubes and vessels are thoroughly inspected to ensure nothing is leaking, and a temporary drainage tube is inserted to draw air, fluid and blood out of the surgical cavity before the chest incision is closed.

Rarely, patients will need to breathe with the assistance of a respirator for one to two days after the operation, and the drainage tubes will remain in place to monitor for bleeding and air leakage. They may be fed and medicated intravenously before being transferred from intensive care to a regular hospital room.

Care during a normal one-week hospitalization focuses on:

  • Relieving pain
  • Monitoring blood oxygen levels
  • Encouraging a patient to cough up accumulated lung secretions
  • Helping the patient walk to prevent the formation of blood clots

Full recovery may take as long as two or three months.

Extrapleural Pneumonectomy

A pneumonectomy is part of a common mesothelioma surgery known as an extrapleural pneumonectomy (EPP), where the affected lung is removed along with parts of the lining of the lung (pleura), heart lining (pericardium), diaphragm and nearby lymph nodes.

The goal of this procedure is to remove as much cancerous tissue as possible from the chest cavity. This slows the cancer’s progression and improves breathing and quality of life.

Although an EPP is considered a more radical approach than other treatments, the procedure can increase a patient’s survival by months or even years. EPP is only available to a select group of pleural mesothelioma patients who are in relatively good health and whose cancer is confined to one chest cavity.

Risks of Lung Removal

The prognosis following a pneumonectomy depends on many factors, including the lung to be removed, the type and stage of a patient’s cancer, and the patient’s gender, age and health.

Approximately 6% of patients struggle with shortness of breath for up to six months following surgery, as the remaining lung gradually takes on the work of two lungs. The risks for any surgical procedure include adverse reactions to medication, bleeding and infection.

Risks for pneumonectomy patients include:

  • Prolonged need for a respirator
  • Heart problems such as cardiac arrhythmia (abnormal heart rhythm) and myocardial infarction (heart attack)
  • Pneumonia
  • Pulmonary edema (fluid accumulation in the lung)
  • A pulmonary embolism (blood clot) in the remaining lung
  • Post-pneumonectomy empyema (infection of the pleural cavity and accumulation of pus in the pleural space)
  • Kidney or other organ failure
  • Bronchopleural fistula (an abnormal fusion of the stump of the cut bronchus and the pleural space)
  • Post-pneumonectomy syndrome (other organs in the chest moving into the space left by the surgery)

A pneumonectomy (or extrapleural pneumonectomy) is a risky procedure. But it can be very helpful for people with mesothelioma. It can make them feel better and give them more time to live. Sometimes it adds months or even years to their lives.

In the United States, doctors have been able to successfully remove a left lung in about 96-98% of cases. For right lung removal, the success rate is slightly lower at 88-90%. This is because it can be more complicated when cutting around the main air tube coming from the lungs.

According to a three-year, multicenter study, pleural mesothelioma patients who underwent EPP had a survival rate of 89.5% survival rate (10.5% mortality rate) within 30 days of surgery.

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