Research is revealing a group of sugars known as beta glucans that can boost immunity and fight bacterial infections. Beta glucan may benefit people with mesothelioma by helping them recover from infections by boosting the immune system.
Beta glucans are sugar compounds found in bacteria, yeast, fungi, algae and plants such as oats and barley. They are a source of soluble fiber and have been used for a variety of medicinal purposes.
They have been used to control high cholesterol, boost the immune system and improve skin conditions such as eczema, bedsores, wounds and radiation therapy burns.
Beta glucans are also considered prebiotics, which are food for the probiotics (good gut bacteria) that live in the human digestive system.
Researchers believe beta glucan deserves further study because it is affordable and has a good track record of safety.
Patients with mesothelioma should discuss beta glucans with their oncologist prior to consumption to be aware of potential interactions and side effects.
Beta glucans are chains of glucose (sugar) that are linked together. They vary in size and structural complexity based on the number of glucose chains that link up.
Larger beta glucans with more chains of glucose appear to have a greater impact on the immune system and better anti-cancer effects.
Beta glucans appear to directly and indirectly boost the immune system.
Once ingested, beta glucans are absorbed in the small intestine and broken into smaller parts. These parts are carried to the bone marrow and immune cells, where they activate various parts of the immune system including anti-cancer cells and compounds.
The anti-cancer cells activated by beta glucan include macrophages, natural killer cells, dendritic cells, neutrophils and monocytes.
The anti-cancer compounds activated by beta glucans include cytokines such as tumor necrosis factor-alpha and several different interleukins. Cytokines are inflammatory chemicals that help the immune system fight diseases such as cancer.
A study published in Cancer Immunology Immunotherapy in 2002 showed beta glucans from barley shrunk tumors and prolonged survival in mice with neuroblastoma, a form of adrenal gland cancer.
According to a 2012 study published in the journal Surgery Today, in 1989, Japan approved a beta-glucan compound in mushrooms for use in combination with chemotherapy to treat gastric cancer and colorectal cancer, and to prolong remission among patients with small-cell lung cancer.
Research does not indicate that beta glucans can directly kill cancer cells. Rather, they stimulate the immune system to kill cancer cells.
There are potential side effects and risks of using beta glucan. Patients should monitor how they feel after supplementing with beta glucan.
Patients with leukemia should not take beta glucan supplements because laboratory studies suggest that beta glucan can promote the growth of leukemia cells.
Doctors and dieticians generally recommend people consume beta glucans through their diet rather than taking a supplement. However, supplements are available and are generally considered safe.
Barley typically has the highest concentration of beta glucans. Oats have the second-highest.
One cup of cooked pearl barley contains 2.5 grams of beta glucans. One and a half cups of cooked oatmeal, or three packets of instant oatmeal, contain 3 grams of beta glucans.
In addition to their anti-cancer properties, beta glucans are beneficial for people with high cholesterol.
A 2016 study published in the British Journal of Nutrition found consuming three grams of oat fiber beta glucan daily decreased levels of bad cholesterol and reduced risk of cardiovascular disease. The U.S. Food and Drug Administration says eating 3 grams of beta glucan a day can lower blood cholesterol levels by 5 percent to 8 percent.
Not enough research has been conducted on beta glucans and cancer for doctors to recommend a specific dosage. This underscores the importance of discussing beta glucan with your oncologist, especially if you are interested in taking a beta glucan supplement.
Joining the team in February 2008 as a writer and editor, Michelle Whitmer has translated medical jargon into patient-friendly information at Asbestos.com for more than eight years. Michelle is a registered yoga teacher, a member of the Academy of Integrative Health & Medicine, and was quoted by The New York Times on the risks of asbestos exposure. Read More