Novel Mesothelioma Treatment Closer to FDA Approval

Treatment & Doctors

Written by Tim Povtak

Reading Time: 3 mins
Publication Date: 09/17/2018
Fact Checked
Our fact-checking process begins with a thorough review of all sources to ensure they are high quality. Then we cross-check the facts with original medical or scientific reports published by those sources, or we validate the facts with reputable news organizations, medical and scientific experts and other health experts. Each page includes all sources for full transparency.
Reviewed is the nation’s most trusted mesothelioma resource

The Mesothelioma Center at has provided patients and their loved ones the most updated and reliable information on mesothelioma and asbestos exposure since 2006.

Our team of Patient Advocates includes a medical doctor, a registered nurse, health services administrators, veterans, VA-accredited Claims Agents, an oncology patient navigator and hospice care expert. Their combined expertise means we help any mesothelioma patient or loved one through every step of their cancer journey.

More than 30 contributors, including mesothelioma doctors, survivors, health care professionals and other experts, have peer-reviewed our website and written unique research-driven articles to ensure you get the highest-quality medical and health information.

About The Mesothelioma Center at

  • Assisting mesothelioma patients and their loved ones since 2006.
  • Helps more than 50% of mesothelioma patients diagnosed annually in the U.S.
  • A+ rating from the Better Business Bureau.
  • 5-star reviewed mesothelioma and support organization.
Learn More About Us


"My family has only the highest compliment for the assistance and support that we received from The Mesothelioma Center. This is a staff of compassionate and knowledgeable individuals who respect what your family is experiencing and who go the extra mile to make an unfortunate diagnosis less stressful. Information and assistance were provided by The Mesothelioma Center at no cost to our family."
Mesothelioma patient’s daughter
  • Google Review Rating
  • BBB Review Rating

How to Cite’s Article


Povtak, T. (2020, October 16). Novel Mesothelioma Treatment Closer to FDA Approval. Retrieved May 30, 2023, from


Povtak, Tim. "Novel Mesothelioma Treatment Closer to FDA Approval.", 16 Oct 2020,


Povtak, Tim. "Novel Mesothelioma Treatment Closer to FDA Approval." Last modified October 16, 2020.

Electric current

Standard-of-care treatment for patients with pleural mesothelioma may soon include Tumor Treating Fields, a novel therapy involving electric fields that disrupt cancer cell division and inhibit tumor growth.

In the wake of recently released results from Novocure’s STELLAR phase II clinical trial, the U.S. Food and Drug Administration (FDA) is expected to approve the treatment within the next six months, giving mesothelioma patients another much-needed option.

“At this point, it should be a relatively rapid approval process,” Dr. Eilon Kirson, chief science officer at Novocure, the oncology company designing the therapy, told “We’ve been working with the FDA to make it happen. The data is approvable, from a clinical trial design point of view, a statistical point of view, and from a clinical benefit point of view.”

The FDA has not approved a new treatment option for pleural mesothelioma since 2004 when the chemotherapy drug Alimta (pemetrexed) was added.

A 50 Percent Improvement

In the STELLAR clinical trial, Tumor Treating Fields was combined with standard chemotherapy — Alimta and either cisplatin or carboplatin — and compared to a historical control model of standard chemotherapy alone.

The results include an 18.2-month median overall survival for the Tumor Treating Fields group, a significant improvement over the 12.1 months for those receiving only chemotherapy. There was no reported increase in systemic toxicity.

“It’s not the cure we’re all looking for, but it means that some patients are seeing a significant benefit,” Kirson said. “It’s a jump forward. If approved, it can change the outcome of this disease, make it that much less horrific.”

The clinical trial was held at multiple cancer centers across Europe and included 80 patients with unresectable, previously untreated, malignant pleural mesothelioma.

Of those patients, 66 percent had the epithelioid histology, 56 percent were smokers, and the median age was 67.

The final results of the trial will be presented later this month in Toronto at the 19th annual World Conference on Lung Cancer, hosted by the International Association for the Study of Lung Cancer.

Secondary endpoints in the trial also showed improvement over the historical controls, which were established in 2003 as part of the Alimta approval. The historical control included a similar percentage of patients with epithelioid histology.

The Tumor Treating Fields median progression-free survival was 7.6 months, compared to 5.7 months. A clinical benefit, which includes either partial response or stable disease, was found in 97.2 percent of patients.

Skin irritation was seen in 46 percent of the patients, but only 4 percent reported grade 3 skin irritation.

Already Approved for Brain Cancer

Tumor Treating Fields was first approved by the FDA in 2011 for use with glioblastoma, the type of brain cancer that recently killed U.S. Sen. John McCain from Arizona. McCain had not been treated with with novel therapy.

The FDA gave Tumor Treating Fields a Humanitarian Use Device designation for pleural mesothelioma in 2017, which provided an opportunity for limited use.

Novocure has been seeking a Humanitarian Device Exemption, which would allow a full, broader use of the therapy for mesothelioma when used with chemotherapy.

The company also is conducting clinical trials for its use with lung cancer, pancreatic cancer and ovarian cancer.

With FDA approval, Kirson said it should be available in 2019 for pleural mesothelioma patients.

“Our mission is to improve patients’ survival without the toxicity you get with systemic chemotherapy,” he said. “If we can move it from treating brain tumors to the chest, it would not only help mesothelioma patients, but it would open the door for treating other cancers, too.”

open book icon vector illustration
Medically Reviewed by Top Mesothelioma Doctors
Free Mesothelioma Guide