Immunotherapy with Surgery Raises Hopes for Mesothelioma Patients

Treatment & Doctors
Reading Time: 3 mins
Publication Date: 06/18/2015
Fact Checked
Our fact-checking process begins with a thorough review of all sources to ensure they are high quality. Then we cross-check the facts with original medical or scientific reports published by those sources, or we validate the facts with reputable news organizations, medical and scientific experts and other health experts. Each page includes all sources for full transparency.
Reviewed is the nation’s most trusted mesothelioma resource

The Mesothelioma Center at has provided patients and their loved ones the most updated and reliable information on mesothelioma and asbestos exposure since 2006.

Our team of Patient Advocates includes a medical doctor, a registered nurse, health services administrators, veterans, VA-accredited Claims Agents, an oncology patient navigator and hospice care expert. Their combined expertise means we help any mesothelioma patient or loved one through every step of their cancer journey.

More than 30 contributors, including mesothelioma doctors, survivors, health care professionals and other experts, have peer-reviewed our website and written unique research-driven articles to ensure you get the highest-quality medical and health information.

About The Mesothelioma Center at

  • Assisting mesothelioma patients and their loved ones since 2006.
  • Helps more than 50% of mesothelioma patients diagnosed annually in the U.S.
  • A+ rating from the Better Business Bureau.
  • 5-star reviewed mesothelioma and support organization.
Learn More About Us


"My family has only the highest compliment for the assistance and support that we received from The Mesothelioma Center. This is a staff of compassionate and knowledgeable individuals who respect what your family is experiencing and who go the extra mile to make an unfortunate diagnosis less stressful. Information and assistance were provided by The Mesothelioma Center at no cost to our family."
Mesothelioma patient’s daughter
  • Google Review Rating
  • BBB Review Rating

How to Cite’s Article


Povtak, T. (2020, October 16). Immunotherapy with Surgery Raises Hopes for Mesothelioma Patients. Retrieved November 29, 2022, from


Povtak, Tim. "Immunotherapy with Surgery Raises Hopes for Mesothelioma Patients.", 16 Oct 2020,


Povtak, Tim. "Immunotherapy with Surgery Raises Hopes for Mesothelioma Patients." Last modified October 16, 2020.

An immunotherapy vaccine by itself won’t stop malignant pleural mesothelioma, but its ability to enhance the effectiveness of cytoreductive surgery could become the treatment breakthrough
that doctors and patients have been seeking for years.

The combination of immunotherapy and surgery, which proved especially effective in preclinical research at the University of Pennsylvania, should add to the multimodal treatment approach that includes chemotherapy and radiation for mesothelioma patients.

“It is very promising,” renowned thoracic surgeon and mesothelioma specialist Dr. Sunil Singhal, of the Abramson Cancer Center, told “It’s way too early to be sure, but this could become a really big deal.”

Singhal, who also serves as director of the Thoracic Surgery Research Laboratory at Penn Medicine, believes reducing the mesothelioma tumor burden with surgery gives the immunotherapy vaccine a much better chance of success.

“What we’ve seen so far is that the vaccine by itself, with advanced disease, doesn’t seem to work very well,” Singhal said. “But if the vaccine can rev up or amplify the immune system, and we take out the tumors, it can attack what’s left over and finish the job. There is real potential here.”

Difficulty Developing the Vaccines

Although preclinical research continues to support the development of an immunotherapy approach or helping a patient’s own immune system to attack the cancer, effective vaccines have been difficult to develop.

Once tumors are advanced and well established, they develop an immunosuppression ability that even the most powerful drugs can’t break. The vaccines are much more effective when delivered in the early stages of cancer.

The laboratory research at UPenn Medicine was detailed last month in Immunology Letters. The conclusion reached: Debulking the tumor can restore the efficacy of vaccine-based immunotherapy. It could become an attractive therapeutic option for mesothelioma patients.

“I’ve always believed that with mesothelioma, you can’t get away with just surgery, or just chemotherapy, or just radiation,” Singhal said. “The best way to handle it is a combination that may eventually include another step.”

Building Momentum with CRS-207

The vaccine used in the laboratory research, and now part of a multicenter clinical trial, was the modified version of Listeria (CRS-207) that has become a popular topic with oncologists around the country.

The genetically modified Listeria virus earlier this year was granted orphan drug designation for mesothelioma by the U.S. Food and Drug Administration (FDA). The designation promotes the research and development of new drugs, especially for rare diseases such as mesothelioma.

The FDA already has approved effective immunotherapy vaccines for more common cancers such as those of the breast, prostate, skin and lungs. But the agency hasn’t approved any for mesothelioma.

Cancer vaccines in the past have produced notable responses in laboratory animals for a variety of malignancies but have not translated well in human trials. CRS-207 is one of the first that has shown particular promise in clinical trials for mesothelioma.

The CRS-207 vaccine produced a 94 percent rate of disease control, either partial response or stable disease, in a recent trial involving patients who were not candidates for surgery.

There has been no clinical trial yet that combines the CRS-207 vaccine with cytoreductive surgery, but the first may not be far away.

“We’re making progress with this very tough disease,” Singhal said. “We’re finally getting some momentum going.”

Medically Reviewed by Top Mesothelioma Doctors
Free Mesothelioma Guide